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Article

Expression Profile of Stemness Markers CD138, Nestin and Alpha-SMA in Ameloblastic Tumours

1
Melbourne Dental School, University of Melbourne, 720 Swanston Street, Carton, VIC 3053, Australia
2
Pathology Unit, Department of Advanced Biomedical Sciences, University Federico II of Naples, 80131 Naples, Italy
3
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, 80131 Naples, Italy
4
Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy
5
Comprehensive Dentistry Department, Faculty of Dentistry, Universitat de Barcelona, L’Hospitalet de Llobregat, 08007 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Takemi Otsuki
Int. J. Environ. Res. Public Health 2021, 18(8), 3899; https://doi.org/10.3390/ijerph18083899
Received: 17 February 2021 / Revised: 23 March 2021 / Accepted: 6 April 2021 / Published: 8 April 2021
(This article belongs to the Special Issue The Impact of ENT Diseases in Social Life)
Ameloblastic carcinoma is a rare malignant odontogenic neoplasm with a poor prognosis. It can arise de novo or from a pre-existing ameloblastoma. Research into stemness marker expression in ameloblastic tumours is lacking. This study aimed to explore the immunohistochemical expression of stemness markers nestin, CD138, and alpha-smooth muscle actin (alpha-SMA) for the characterisation of ameloblastic tumours. Six cases of ameloblastoma and four cases of ameloblastic carcinoma were assessed, including one case of ameloblastic carcinoma arising from desmoplastic ameloblastoma. In all tumour samples, CD138 was positive, whilst alpha-SMA was negative. Nestin was negative in all but one tumour sample. Conversely, the presence or absence of these markers varied in stroma samples. Nestin was observed in one ameloblastic carcinoma stroma sample, whilst CD138 was positive in one ameloblastoma case, one desmoplastic ameloblastoma case, and in two ameloblastic carcinoma stroma samples. Finally, alpha-SMA was found positive only in the desmoplastic ameloblastoma stroma sample. Our results suggest nestin expression to be an indicator for ameloblastic carcinoma, and CD138 and alpha-SMA to be promising biomarkers for the malignant transformation of ameloblastoma. Our data showed that nestin, CD138, and alpha-SMA are novel biomarkers for a better understanding of the origins and behaviour of ameloblastic tumours. View Full-Text
Keywords: ameloblastoma; ameloblastic carcinoma; nestin; CD138; syndecan-1; alpha-SMA; stemness markers ameloblastoma; ameloblastic carcinoma; nestin; CD138; syndecan-1; alpha-SMA; stemness markers
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MDPI and ACS Style

Yiannis, C.; Mascolo, M.; Mignogna, M.D.; Varricchio, S.; Natella, V.; De Rosa, G.; Lo Giudice, R.; Galletti, C.; Paolini, R.; Celentano, A. Expression Profile of Stemness Markers CD138, Nestin and Alpha-SMA in Ameloblastic Tumours. Int. J. Environ. Res. Public Health 2021, 18, 3899. https://doi.org/10.3390/ijerph18083899

AMA Style

Yiannis C, Mascolo M, Mignogna MD, Varricchio S, Natella V, De Rosa G, Lo Giudice R, Galletti C, Paolini R, Celentano A. Expression Profile of Stemness Markers CD138, Nestin and Alpha-SMA in Ameloblastic Tumours. International Journal of Environmental Research and Public Health. 2021; 18(8):3899. https://doi.org/10.3390/ijerph18083899

Chicago/Turabian Style

Yiannis, Callisthenis, Massimo Mascolo, Michele D. Mignogna, Silvia Varricchio, Valentina Natella, Gaetano De Rosa, Roberto Lo Giudice, Cosimo Galletti, Rita Paolini, and Antonio Celentano. 2021. "Expression Profile of Stemness Markers CD138, Nestin and Alpha-SMA in Ameloblastic Tumours" International Journal of Environmental Research and Public Health 18, no. 8: 3899. https://doi.org/10.3390/ijerph18083899

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