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Article

Health-Related Quality of Life in Weight Loss Interventions: Results from the OPTIWIN Trial

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Nestlé Research, Nestlé, 1000 Lausanne, Switzerland
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EpidStrategies, Durham, NC 27101, USA
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Nestlé Health Science, Nestlé, 1015 Lausanne, Switzerland
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Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
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Alaska Premier Health, Anchorage, AK 99503, USA
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The Central Ohio Nutrition Center, Inc., Gohanna, OH 43230, USA
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Department of Surgery, Brody School of Medicine, East Carolina University, Greenville, NC 27101, USA
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Department of Nutritional Sciences, School of Public Health and Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Harbour, MI 48109-2029, USA
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Author to whom correspondence should be addressed.
Academic Editors: David Berrigan and Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(4), 1785; https://doi.org/10.3390/ijerph18041785
Received: 23 December 2020 / Revised: 8 February 2021 / Accepted: 9 February 2021 / Published: 12 February 2021
Obesity is highly prevalent and associated with several adverse outcomes including health-related quality-of-life (HRQoL), work productivity, and activity impairment. The objective of this study is to examine group differences in HRQoL and labor-related health outcomes among participants in the OPTIWIN program, which compared the effectiveness of two intensive behavioral weight loss interventions. Participants (n = 273) were randomized to OPTIFAST®(OP) or food-based (FB) dietary interventions for 52 weeks. HRQoL and labor-related health outcomes were measured at baseline, week 26, and week 52, using two questionnaires. At baseline, there were no differences between groups on the Impact of Weight on Quality-of-Life Questionnaire (IWQOL-Lite). At week 26, the OP group had statistically significant differences towards better HRQoL for Physical Function, Self-Esteem, and the total score compared with the FB group. At week 52, the OP group showed better HRQoL in the total score (p = 0.0012) and in all but one domain. Moreover, the adjusted change-from-baseline normalized total score at week 52 was −5.9 points (p = 0.0001). Finally, the mean IWQOL-Lite normalized score showed that HRQoL improves by 0.4442 units (p < 0.0001) per kg lost, and that greater weight reduction was positively associated with better HRQoL. No statistically significant group differences were found with the Work Productivity and Activity Impairment (General Health) (WPAI-GH) Questionnaire. HRQoL improves with highly intensive, well-structured weight loss interventions. Greater weight loss lead to larger improvements. The lack of negative effect on productivity and activity suggests that these interventions may be compatible with an active work lifestyle. View Full-Text
Keywords: obesity; health-related quality-of-life; weight loss interventions; IWQOL-Lite; WPAI-GH obesity; health-related quality-of-life; weight loss interventions; IWQOL-Lite; WPAI-GH
MDPI and ACS Style

Dainelli, L.; Luo, D.R.; Cohen, S.S.; Marczewska, A.; Ard, J.D.; Coburn, S.L.; Lewis, K.H.; Loper, J.; Matarese, L.E.; Pories, W.J.; Rothberg, A.E. Health-Related Quality of Life in Weight Loss Interventions: Results from the OPTIWIN Trial. Int. J. Environ. Res. Public Health 2021, 18, 1785. https://doi.org/10.3390/ijerph18041785

AMA Style

Dainelli L, Luo DR, Cohen SS, Marczewska A, Ard JD, Coburn SL, Lewis KH, Loper J, Matarese LE, Pories WJ, Rothberg AE. Health-Related Quality of Life in Weight Loss Interventions: Results from the OPTIWIN Trial. International Journal of Environmental Research and Public Health. 2021; 18(4):1785. https://doi.org/10.3390/ijerph18041785

Chicago/Turabian Style

Dainelli, Livia, Dan R. Luo, Sarah S. Cohen, Agnieszka Marczewska, Jamy D. Ard, Sally L. Coburn, Kristina H. Lewis, Judy Loper, Laura E. Matarese, Walter J. Pories, and Amy E. Rothberg. 2021. "Health-Related Quality of Life in Weight Loss Interventions: Results from the OPTIWIN Trial" International Journal of Environmental Research and Public Health 18, no. 4: 1785. https://doi.org/10.3390/ijerph18041785

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