XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case–Control Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. TagSNPs Selection and Genotype
2.3. Statistical Analysis
3. Results
3.1. Baseline Characteristics of Study Population
3.2. Selected SNPs and the Risk of Gastric Cancer
3.3. XAB2 rs794078 Variant and Gastric Cancer by Smoking Status
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Chen, W.; Sun, K.; Zheng, R.; Zeng, H.; Zhang, S.; Xia, C.; Yang, Z.; Li, H.; Zou, X.; He, J. Cancer incidence and mortality in China, 2014. Chin. J. Cancer Res. 2018, 30, 1–12. [Google Scholar] [CrossRef]
- Jemal, A.; Center, M.M.; DeSantis, C.; Ward, E.M. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol. Biomark. Prev. 2010, 19, 1893–1907. [Google Scholar] [CrossRef] [Green Version]
- Karimi, P.; Islami, F.; Anandasabapathy, S.; Freedman, N.D.; Kamangar, F. Gastric cancer: Descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol. Biomark. Prev. 2014, 23, 700–713. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Oliveira, C.; Pinheiro, H.; Figueiredo, J.; Seruca, R.; Carneiro, F. Familial gastric cancer: Genetic susceptibility, pathology, and implications for management. Lancet Oncol. 2015, 16, e60–e70. [Google Scholar] [CrossRef]
- Mocellin, S.; Verdi, D.; Pooley, K.A.; Nitti, D. Genetic variation and gastric cancer risk: A field synopsis and meta-analysis. Gut 2015, 64, 1209–1219. [Google Scholar] [CrossRef] [Green Version]
- Decordier, I.; Loock, K.V.; Kirsch-Volders, M. Phenotyping for DNA repair capacity. Mutat. Res. 2010, 705, 107–129. [Google Scholar] [CrossRef] [PubMed]
- Ramos, J.M.; Ruiz, A.; Colen, R.; Lopez, I.D.; Grossman, L.; Matta, J.L. DNA repair and breast carcinoma susceptibility in women. Cancer 2004, 100, 1352–1357. [Google Scholar] [CrossRef]
- Marteijn, J.A.; Lans, H.; Vermeulen, W.; Hoeijmakers, J.H. Understanding nucleotide excision repair and its roles in cancer and ageing. Nat. Rev. Mol. Cell Biol. 2014, 15, 465–481. [Google Scholar] [CrossRef] [PubMed]
- Hoeijmakers, J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411, 366–374. [Google Scholar] [CrossRef]
- Iyama, T.; Wilson, D.M., 3rd. DNA repair mechanisms in dividing and non-dividing cells. DNA Repair 2013, 12, 620–636. [Google Scholar] [CrossRef] [Green Version]
- Godon, C.; Mourgues, S.; Nonnekens, J.; Mourcet, A.; Coin, F.; Vermeulen, W.; Mari, P.O.; Giglia-Mari, G. Generation of DNA single-strand displacement by compromised nucleotide excision repair. EMBO J. 2012, 31, 3550–3563. [Google Scholar] [CrossRef] [Green Version]
- Gong, Y.; He, C.; Duan, Z.; Sun, L.; Xu, Q.; Xing, C.; Yuan, Y. Association of two ERCC4 tagSNPs with susceptibility to atrophic gastritis and gastric cancer in Chinese. Gene 2013, 519, 335–342. [Google Scholar] [CrossRef] [PubMed]
- Lu, B.; Li, J.; Gao, Q.; Yu, W.; Yang, Q.; Li, X. Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. Gene 2014, 542, 64–68. [Google Scholar] [CrossRef]
- Du, H.; Guo, N.; Shi, B.; Zhang, Q.; Chen, Z.; Lu, K.; Shu, Y.; Chen, T.; Zhu, L. The effect of XPD polymorphisms on digestive tract cancers risk: A meta-analysis. PLoS ONE 2014, 9, e96301. [Google Scholar]
- Kuraoka, I.; Ito, S.; Wada, T.; Hayashida, M.; Lee, L.; Saijo, M.; Nakatsu, Y.; Matsumoto, M.; Matsunaga, T.; Handa, H.; et al. Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair. J. Biol. Chem. 2008, 283, 940–950. [Google Scholar] [CrossRef] [Green Version]
- Nakatsu, Y.; Asahina, H.; Citterio, E.; Rademakers, S.; Vermeulen, W.; Kamiuchi, S.; Yeo, J.P.; Khaw, M.C.; Saijo, M.; Kodo, N.; et al. XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. J. Biol. Chem. 2000, 275, 34931–34937. [Google Scholar] [CrossRef] [Green Version]
- Yonemasu, R.; Minami, M.; Nakatsu, Y.; Takeuchi, M.; Kuraoka, I.; Matsuda, Y.; Higashi, Y.; Kondoh, H.; Tanaka, K. Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality. DNA Repair 2005, 4, 479–491. [Google Scholar] [CrossRef]
- Fousteri, M.; Mullenders, L.H. Transcription-coupled nucleotide excision repair in mammalian cells: Molecular mechanisms and biological effects. Cell Res. 2008, 18, 73–84. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ritchie, M.D.; Hahn, L.W.; Moore, J.H. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet. Epidemiol. 2003, 24, 150–157. [Google Scholar] [CrossRef]
- Ohnuma-Ishikawa, K.; Morio, T.; Yamada, T.; Sugawara, Y.; Ono, M.; Nagasawa, M.; Yasuda, A.; Morimoto, C.; Ohnuma, K.; Dang, N.H.; et al. Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells. Cancer Res. 2007, 67, 1019–1029. [Google Scholar] [CrossRef] [Green Version]
- Fousteri, M.; Vermeulen, W.; van Zeeland, A.A.; Mullenders, L.H. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol. Cell 2006, 23, 471–482. [Google Scholar] [CrossRef]
- Song, Q.; Zhang, Z.; Liu, Y.; Han, S.; Zhang, X. The tag SNP rs10746463 in decay-accelerating factor is associated with the susceptibility to gastric cancer. Mol. Immunol. 2015, 63, 473–478. [Google Scholar] [CrossRef]
- Hussain, S.K.; Mu, L.N.; Cai, L.; Chang, S.C.; Park, S.L.; Oh, S.S.; Wang, Y.; Goldstein, B.Y.; Ding, B.G.; Jiang, Q.; et al. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. Cancer Epidemiol. Biomark. Prev. 2009, 18, 2304–2309. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Wyss, A.B.; Herring, A.H.; Avery, C.L.; Weissler, M.C.; Bensen, J.T.; Barnholtz-Sloan, J.S.; Funkhouser, W.K.; Olshan, A.F. Single-nucleotide polymorphisms in nucleotide excision repair genes, cigarette smoking, and the risk of head and neck cancer. Cancer Epidemiol. Biomark. Prev. 2013, 22, 1428–1445. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Dixit, K.; Ahmad, S.; Shahab, U.; Habib, S.; Naim, M.; Alam, K.; Ali, A. Human DNA damage by the synergistic action of 4-aminobiphenyl and nitric oxide: An immunochemical study. Environ. Toxicol. 2014, 29, 568–576. [Google Scholar]
- Tramacere, I.; La Vecchia, C.; Negri, E. Tobacco smoking and esophageal and gastric cardia adenocarcinoma: A meta-analysis. Epidemiology 2011, 22, 344–349. [Google Scholar] [CrossRef]
- Yang, J.J.; Ko, K.P.; Cho, L.Y.; Shin, A.; Gwack, J.; Chang, S.H.; Shin, H.R.; Yoo, K.Y.; Kang, D.; Park, S.K. The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: A nested case-control study. BMC Cancer 2009, 9, 238. [Google Scholar] [CrossRef] [Green Version]
- Han, F.; Wang, X.; Wang, X.; Luo, Y.; Li, W. Meta-analysis of the association of CYP1A1 polymorphisms with gastric cancer susceptibility and interaction with tobacco smoking. Mol. Biol. Rep. 2012, 39, 8335–8344. [Google Scholar] [CrossRef]
Variables | Cases (n = 500) | Controls (n = 500) | p Value | ||
---|---|---|---|---|---|
No | (%) | No | (%) | ||
Sex | 0.407 | ||||
Male | 357 | 71.4 | 344 | 68.8 | |
Female | 143 | 28.6 | 156 | 31.2 | |
Age | 0.317 | ||||
≤50 | 141 | 28.2 | 156 | 31.2 | |
51–60 | 149 | 29.8 | 157 | 31.4 | |
>60 | 210 | 42.0 | 187 | 37.4 | |
Smoking status | 0.652 | ||||
Nonsmoker | 294 | 58.8 | 302 | 60.4 | |
Smoker | 206 | 41.2 | 198 | 39.6 |
Genotypes | Controls (n = 500) | Cases (n = 500) | OR (95% CI) § | p Value | ||
---|---|---|---|---|---|---|
No | (%) | No | (%) | |||
rs4134860 | ||||||
TT | 363 | 72.6 | 350 | 70 | ||
CT | 127 | 25.4 | 136 | 27.2 | 1.10 (0.83–1.46) | 0.51 |
CC | 10 | 2 | 14 | 2.8 | 1.47 (0.64–3.37) | 0.367 |
rs794078 | ||||||
GG | 392 | 78.4 | 378 | 75.6 | ||
AG | 93 | 18.6 | 117 | 23.4 | 1.29 (0.95–1.76) | 0.105 |
AA | 15 | 3 | 5 | 1 | 0.33 (0.12–0.91) | 0.032 |
rs794083 | ||||||
CC | 241 | 48.2 | 237 | 47.4 | ||
CG | 199 | 39.8 | 209 | 41.8 | 1.07 (0.82–1.39) | 0.638 |
GG | 60 | 12 | 54 | 10.8 | 0.93 (0.61–1.40) | 0.71 |
rs4134816 | ||||||
TT | 461 | 92.2 | 470 | 94 | ||
CT | 39 | 7.8 | 30 | 6 | 0.81 (0.49–1.34) | 0.411 |
rs4134819 | ||||||
AA | 129 | 25.8 | 112 | 22.4 | ||
AG | 246 | 49.2 | 253 | 50.6 | 1.18 (0.87–1.62) | 0.287 |
GG | 125 | 25 | 135 | 27 | 1.26 (0.89–1.80) | 0.199 |
Models | Training Bal. | Testing Bal. | p Value | Cross-Validation |
---|---|---|---|---|
Acc (%) | Acc. (%) | Consistency | ||
rs794078 | 52.40 | 51.68 | 0.055 | 9/10 |
rs794078, rs4134819 | 53.38 | 50.22 | 0.623 | 8/10 |
rs794078, rs794083, rs4134819 | 54.29 | 50.01 | 0.623 | 4/10 |
Genotype | Smoking Status | |||||
---|---|---|---|---|---|---|
Nonsmoker (Cases/Controls) | OR (95% CI) § | p Value | Smoker (Cases/Control) | OR (95% CI) § | p Value | |
GG | 229/243 | 1.00 (reference) | 149/149 | 1.02 (0.74–1.42) | 0.891 | |
AG | 61/53 | 1.21 (0.81–1.83) | 0.354 | 56/40 | 1.47 (0.92–2.34) | 0.107 |
AA | 4/6 | 0.69 (0.19–2.48) | 0.567 | 1/9 | 0.11 (0.01–0.91) | 0.04 |
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Xie, Y.; Yu, Y.; Wu, H.; Gao, H.; Yang, Z.; Zhang, Y.; Zhang, X. XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case–Control Study. Int. J. Environ. Res. Public Health 2021, 18, 1494. https://doi.org/10.3390/ijerph18041494
Xie Y, Yu Y, Wu H, Gao H, Yang Z, Zhang Y, Zhang X. XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case–Control Study. International Journal of Environmental Research and Public Health. 2021; 18(4):1494. https://doi.org/10.3390/ijerph18041494
Chicago/Turabian StyleXie, Yuning, Yuan Yu, Hongjiao Wu, Hui Gao, Zhenbang Yang, Yi Zhang, and Xuemei Zhang. 2021. "XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case–Control Study" International Journal of Environmental Research and Public Health 18, no. 4: 1494. https://doi.org/10.3390/ijerph18041494