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Volume 18
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10.3390/ijerph182010849
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Article

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

by
Neeranuch Suwannarin
1,2,3,
Tippawan Prapamontol
2,*,
Tomohiko Isobe
3,
Yukiko Nishihama
3,
Ampica Mangklabruks
4,
Tawiwan Pantasri
5,
Somporn Chantara
6,
Warangkana Naksen
7 and
Shoji F. Nakayama
3,*
1
Ph.D. Degree Program in Environmental Science, Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
2
Environmental and Occupational Health Sciences and Non-Communicable Diseases Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
3
Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan
4
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
5
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
6
Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
7
Faculty of Public Health, Chiang Mai University, Chiang Mai 50200, Thailand
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(20), 10849; https://doi.org/10.3390/ijerph182010849
Submission received: 26 July 2021 / Revised: 1 October 2021 / Accepted: 13 October 2021 / Published: 15 October 2021
(This article belongs to the Section Global Health)
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Abstract

Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.
Keywords: organophosphates; dialkylphosphates; neonicotinoids; insecticides; metabolites; haematological parameters; farmworker; occupational health; environmental health organophosphates; dialkylphosphates; neonicotinoids; insecticides; metabolites; haematological parameters; farmworker; occupational health; environmental health

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MDPI and ACS Style

Suwannarin, N.; Prapamontol, T.; Isobe, T.; Nishihama, Y.; Mangklabruks, A.; Pantasri, T.; Chantara, S.; Naksen, W.; Nakayama, S.F. Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand. Int. J. Environ. Res. Public Health 2021, 18, 10849. https://doi.org/10.3390/ijerph182010849

AMA Style

Suwannarin N, Prapamontol T, Isobe T, Nishihama Y, Mangklabruks A, Pantasri T, Chantara S, Naksen W, Nakayama SF. Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand. International Journal of Environmental Research and Public Health. 2021; 18(20):10849. https://doi.org/10.3390/ijerph182010849

Chicago/Turabian Style

Suwannarin, Neeranuch, Tippawan Prapamontol, Tomohiko Isobe, Yukiko Nishihama, Ampica Mangklabruks, Tawiwan Pantasri, Somporn Chantara, Warangkana Naksen, and Shoji F. Nakayama. 2021. "Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand" International Journal of Environmental Research and Public Health 18, no. 20: 10849. https://doi.org/10.3390/ijerph182010849

APA Style

Suwannarin, N., Prapamontol, T., Isobe, T., Nishihama, Y., Mangklabruks, A., Pantasri, T., Chantara, S., Naksen, W., & Nakayama, S. F. (2021). Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand. International Journal of Environmental Research and Public Health, 18(20), 10849. https://doi.org/10.3390/ijerph182010849

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