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From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?

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INAIL, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, via Fontana Candida 1, 00078 Monte Porzio Catone, Italy
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IRCCS San Raffele Scientific Institute, Reproductive Sciences Laboratory, Obstetrics and Gynaecology Unit, via Olgettina 60, 20132 Milan, Italy
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IRCCS San Raffaele Scientific Institute, Obstetrics and Gynecology Unit, via Olgettina 60, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(2), 532; https://doi.org/10.3390/ijerph18020532
Received: 23 November 2020 / Revised: 30 December 2020 / Accepted: 6 January 2021 / Published: 11 January 2021
(This article belongs to the Section Occupational Safety and Health)
Endometriosis is a gynecological disorder characterized by the presence of endometrial stroma and glands outside the uterine cavity. A systematic review of the literature was conducted to clarify, starting from environmental exposure data, whether possible occupational risk factors may correlate with the onset of the disease. The guidelines for reporting systematic reviews of the “PRISMA” statement were followed and two databases, Scopus and PubMed, were used. Of the 422 studies selected with specific keywords, 32 publications were eligible, 28 of which referred to chemical agents and 4 related to night work. Conflicting data emerged among these studies. Although some compounds seemed to be more involved than others in the onset of endometriosis. Association with exposure to organochlorine compounds is the most supported by the epidemiological data, while other pesticide exposure did not show any clear correlation. Likewise, the hypothesis of a correlation with perfluoroalkyls exposure is not currently supported by data. The involvement of metals as risk factors has not been confirmed, while the role of night work, in the case of long service, seems to play an etiological role. In order to clarify the potential occupational risk of endometriosis development, well-designed studies are needed to evaluate the potential association between chemical compounds and disease etiology. View Full-Text
Keywords: endometriosis; endocrine disrupters; effects at low doses; workers; night shift endometriosis; endocrine disrupters; effects at low doses; workers; night shift
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MDPI and ACS Style

Caporossi, L.; Capanna, S.; Viganò, P.; Alteri, A.; Papaleo, B. From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis? Int. J. Environ. Res. Public Health 2021, 18, 532. https://doi.org/10.3390/ijerph18020532

AMA Style

Caporossi L, Capanna S, Viganò P, Alteri A, Papaleo B. From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis? International Journal of Environmental Research and Public Health. 2021; 18(2):532. https://doi.org/10.3390/ijerph18020532

Chicago/Turabian Style

Caporossi, Lidia, Silvia Capanna, Paola Viganò, Alessandra Alteri, and Bruno Papaleo. 2021. "From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?" International Journal of Environmental Research and Public Health 18, no. 2: 532. https://doi.org/10.3390/ijerph18020532

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