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Review

The Bayesian Design of Adaptive Clinical Trials

Department of Statistical Sciences, University of Bologna, 40126 Bologna, Italy
Retired.
Int. J. Environ. Res. Public Health 2021, 18(2), 530; https://doi.org/10.3390/ijerph18020530
Received: 25 November 2020 / Revised: 31 December 2020 / Accepted: 6 January 2021 / Published: 10 January 2021
(This article belongs to the Special Issue Bayesian Design in Clinical Trials)
This paper presents a brief overview of the recent literature on adaptive design of clinical trials from a Bayesian perspective for statistically not so sophisticated readers. Adaptive designs are attracting a keen interest in several disciplines, from a theoretical viewpoint and also—potentially—from a practical one, and Bayesian adaptive designs, in particular, have raised high expectations in clinical trials. The main conceptual tools are highlighted here, with a mention of several trial designs proposed in the literature that use these methods, including some of the registered Bayesian adaptive trials to this date. This review aims at complementing the existing ones on this topic, pointing at further interesting reading material. View Full-Text
Keywords: adaptive designs; adaptive randomization; Bayesian designs; clinical trials; predictive power; target allocation adaptive designs; adaptive randomization; Bayesian designs; clinical trials; predictive power; target allocation
MDPI and ACS Style

Giovagnoli, A. The Bayesian Design of Adaptive Clinical Trials. Int. J. Environ. Res. Public Health 2021, 18, 530. https://doi.org/10.3390/ijerph18020530

AMA Style

Giovagnoli A. The Bayesian Design of Adaptive Clinical Trials. International Journal of Environmental Research and Public Health. 2021; 18(2):530. https://doi.org/10.3390/ijerph18020530

Chicago/Turabian Style

Giovagnoli, Alessandra. 2021. "The Bayesian Design of Adaptive Clinical Trials" International Journal of Environmental Research and Public Health 18, no. 2: 530. https://doi.org/10.3390/ijerph18020530

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