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Review

Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders

Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
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Int. J. Environ. Res. Public Health 2021, 18(2), 511; https://doi.org/10.3390/ijerph18020511
Received: 9 December 2020 / Revised: 22 December 2020 / Accepted: 6 January 2021 / Published: 10 January 2021
NLRP3 inflammasome is one of the multimeric protein complexes of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing pyrin and HIN domain family (PYHIN). When activated, NLRP3 inflammasome triggers the release of pro-inflammatory interleukins (IL)-1β and IL-18, an essential step in innate immune response; however, defective checkpoints in inflammasome activation may lead to autoimmune, autoinflammatory, and metabolic disorders. Among the consequences of NLRP3 inflammasome activation is systemic chronic low-grade inflammation, a cardinal feature of obesity and insulin resistance. Understanding the mechanisms involved in the regulation of NLRP3 inflammasome in adipose tissue may help in the development of specific inhibitors for the treatment and prevention of obesity-mediated metabolic diseases. In this narrative review, the current understanding of NLRP3 inflammasome activation and regulation is highlighted, including its putative roles in adipose tissue dysfunction and insulin resistance. Specific inhibitors of NLRP3 inflammasome activation which can potentially be used to treat metabolic disorders are also discussed. View Full-Text
Keywords: NLRP3 inflammasome; metabolic stress; insulin resistance; diabetes; obesity NLRP3 inflammasome; metabolic stress; insulin resistance; diabetes; obesity
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MDPI and ACS Style

Wani, K.; AlHarthi, H.; Alghamdi, A.; Sabico, S.; Al-Daghri, N.M. Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders. Int. J. Environ. Res. Public Health 2021, 18, 511. https://doi.org/10.3390/ijerph18020511

AMA Style

Wani K, AlHarthi H, Alghamdi A, Sabico S, Al-Daghri NM. Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders. International Journal of Environmental Research and Public Health. 2021; 18(2):511. https://doi.org/10.3390/ijerph18020511

Chicago/Turabian Style

Wani, Kaiser, Hind AlHarthi, Amani Alghamdi, Shaun Sabico, and Nasser M. Al-Daghri. 2021. "Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders" International Journal of Environmental Research and Public Health 18, no. 2: 511. https://doi.org/10.3390/ijerph18020511

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