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Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data

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School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia
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Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong 3220, Australia
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Departments of Pediatrics and Epidemiology, Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA 98195, USA
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Health Data Research UK, Swansea University, Swansea SA2 8PP, UK
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National Centre for Population Health and Wellbeing Research, Swansea University, Swansea SA2 8PP, UK
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School of Population Health, University of Auckland, Auckland 1023, New Zealand
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Kidz First Hospital and Population Health Directorate, Counties Manukau District Health Board, Auckland 2025, New Zealand
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Department of Pediatrics, School of Population and Public Health, University of British Columbia, Vancouver, BC V6H 3V4, Canada
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British Columbia Injury Research and Prevention Unit, British Columbia Children’s Hospital Research Institute, Vancouver, BC V6H 3V4, Canada
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Human Early Learning Partnership, School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
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Centre for Urgent and Emergency Care Research, School of Health and Related Research, University of Sheffield, Sheffield S10 2TN, UK
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Emergency Department, Salford Royal Hospital, Salford M6 8HD, UK
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South Australian Health and Medical Research Institute, Adelaide 5001, Australia
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College of Medicine and Public Health, Flinders University, Bedford Park 5042, Australia
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School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
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Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(19), 10156; https://doi.org/10.3390/ijerph181910156
Received: 29 July 2021 / Revised: 11 September 2021 / Accepted: 16 September 2021 / Published: 27 September 2021
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population. View Full-Text
Keywords: health-related quality of life; health outcomes; disability; trauma; injury; EQ-5D; children; pediatric; adolescents health-related quality of life; health outcomes; disability; trauma; injury; EQ-5D; children; pediatric; adolescents
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MDPI and ACS Style

Dipnall, J.F.; Rivara, F.P.; Lyons, R.A.; Ameratunga, S.; Brussoni, M.; Lecky, F.E.; Bradley, C.; Beck, B.; Lyons, J.; Schneeberg, A.; Harrison, J.E.; Gabbe, B.J. Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data. Int. J. Environ. Res. Public Health 2021, 18, 10156. https://doi.org/10.3390/ijerph181910156

AMA Style

Dipnall JF, Rivara FP, Lyons RA, Ameratunga S, Brussoni M, Lecky FE, Bradley C, Beck B, Lyons J, Schneeberg A, Harrison JE, Gabbe BJ. Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data. International Journal of Environmental Research and Public Health. 2021; 18(19):10156. https://doi.org/10.3390/ijerph181910156

Chicago/Turabian Style

Dipnall, Joanna F., Frederick P. Rivara, Ronan A. Lyons, Shanthi Ameratunga, Mariana Brussoni, Fiona E. Lecky, Clare Bradley, Ben Beck, Jane Lyons, Amy Schneeberg, James E. Harrison, and Belinda J. Gabbe. 2021. "Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data" International Journal of Environmental Research and Public Health 18, no. 19: 10156. https://doi.org/10.3390/ijerph181910156

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