Next Article in Journal
The Impact of the COVID-19 Pandemic on the Working Lives and Retirement Timing of Older Nurses in Ireland
Next Article in Special Issue
Cerebellar Agenesis and Bilateral Polimicrogyria Associated with Rare Variants of CUB and Sushi Multiple Domains 1 Gene (CSMD1): A Longitudinal Neuropsychological and Neuroradiological Case Study
Previous Article in Journal
Are Spaniards Happier When the Bars Are Open? Using Life Satisfaction to Evaluate COVID-19 Non-Pharmaceutical Interventions (NPIs)
Previous Article in Special Issue
Mechanisms of Ethanol-Induced Cerebellar Ataxia: Underpinnings of Neuronal Death in the Cerebellum
Communication

Identification of the Prodromal Symptoms and Pre-Ataxic Stage in Cerebellar Disorders: The Next Challenge

1
Unité des Ataxies Cérébelleuses, Department of Neurology, Médiathèque Jean Jacquy, CHU-Charleroi, 6000 Charleroi, Belgium
2
Department of Neurosciences, Université de Mons, 7034 Mons, Belgium
3
Louis Stokes Cleveland VA Medical Center, University Hospitals Cleveland Medical Center, Cleveland, OH 44022, USA
4
Department of Medical Education, Tokyo Medical University, Tokyo 160-0023, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(19), 10057; https://doi.org/10.3390/ijerph181910057
Received: 24 August 2021 / Revised: 20 September 2021 / Accepted: 23 September 2021 / Published: 24 September 2021
(This article belongs to the Special Issue New Horizons in Cerebellar Research)
Cerebellar ataxias (CAs) manifest with a combination of motor incoordination, cognitive, affective and recently identified social symptoms. Novel therapies aim to stop the progression of the subgroup of the degenerative ataxias, or even to cure the disease with a functional and anatomical restoration of the cerebellar circuitry in the near future. The goal of stopping the progression of the disease is particularly relevant if applied at a very early stage of the disease, when the cerebellar reserve is only slightly impaired. Therefore, the search of the prodromal phase or pre-ataxic stage of CAs represents a very important challenge for the scientific community. The identification of pre-manifest individuals and the recruitment of individuals at risk has become a key-challenge to address neuroprotective therapies. The feasibility is high due to the recent progress in the biological and morphological biomarkers of CAs. View Full-Text
Keywords: cerebellum; ataxias; prodromal; preataxic; cerebellar reserve cerebellum; ataxias; prodromal; preataxic; cerebellar reserve
Show Figures

Figure 1

MDPI and ACS Style

Manto, M.; Shaikh, A.G.; Mitoma, H. Identification of the Prodromal Symptoms and Pre-Ataxic Stage in Cerebellar Disorders: The Next Challenge. Int. J. Environ. Res. Public Health 2021, 18, 10057. https://doi.org/10.3390/ijerph181910057

AMA Style

Manto M, Shaikh AG, Mitoma H. Identification of the Prodromal Symptoms and Pre-Ataxic Stage in Cerebellar Disorders: The Next Challenge. International Journal of Environmental Research and Public Health. 2021; 18(19):10057. https://doi.org/10.3390/ijerph181910057

Chicago/Turabian Style

Manto, Mario, Aasef G. Shaikh, and Hiroshi Mitoma. 2021. "Identification of the Prodromal Symptoms and Pre-Ataxic Stage in Cerebellar Disorders: The Next Challenge" International Journal of Environmental Research and Public Health 18, no. 19: 10057. https://doi.org/10.3390/ijerph181910057

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop