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Article

Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents

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Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre—UFCSPA, Sarmento Leite St, 245, Centro Histórico, Porto Alegre 90050-170, Brazil
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Graduate Program in Health Promotion, University of Santa Cruz do Sul, Independência Av. 2293-Universitário, Santa Cruz do Sul 96815-900, Brazil
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Department of Health, Kinesiology, and Recreation, University of Utah, 201 Presidents’ Cir, Salt Lake City, UT 84112, USA
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Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 28083 Madrid, Spain
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Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre—UFCSPA, Sarmento Leite St, 245, Centro Histórico, Porto Alegre 90690-200, Brazil
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Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90690-200, Brazil
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Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(18), 9797; https://doi.org/10.3390/ijerph18189797
Received: 9 August 2021 / Revised: 10 September 2021 / Accepted: 14 September 2021 / Published: 17 September 2021
The human locus FNDC5 rs16835198 contributes positively to anthropometric phenotypes in children and adolescents. However, the role of specific components of physical fitness in this relationship is not known. The present study aimed to verify the moderator role of cardiorespiratory fitness (CRF) and muscular strength in the relationship between rs16835198 polymorphism FNDC5 and adiposity in children and adolescents. This cross-sectional study was carried out by genotyping the rs16835198 FNDC5 polymorphism in 1701 children and adolescents (mean age 11.73 ± 2.75 years). Obesity was assessed using waist circumference and body mass index (BMI) z-scores. To evaluate CRF and muscular strength, the 6 min run/walk test and lower limb strength (LLS) were used. Linear regression models were applied, and all analyses were adjusted for age, sex, skin color, living area, and school type. A significant interaction term for CRF (p = 0.038) and LLS (p = 0.040) × rs16835198 FNDC5 with WC was identified. Regarding BMI, a significant interaction term for CRF (p = 0.007) and LLS (p = 0.044) × rs16835198 FNDC5 was observed. Moreover, medium and high CRF and LLS levels protected against higher WC and BMI. In conclusion, adiposity levels of children and adolescents with a genetic predisposition to obesity might be modified by improving CRF and muscular strength. View Full-Text
Keywords: genetics; physical fitness; obesity; children; adolescents genetics; physical fitness; obesity; children; adolescents
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MDPI and ACS Style

Todendi, P.F.; Brand, C.; de Castro Silveira, J.F.; Burns, R.D.; Martínez, J.A.; Fiegenbaum, M.; Reis Gaya, A.; Pollo Renner, J.D.; Reuter, C.P.; de Moura Valim, A.R. Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents. Int. J. Environ. Res. Public Health 2021, 18, 9797. https://doi.org/10.3390/ijerph18189797

AMA Style

Todendi PF, Brand C, de Castro Silveira JF, Burns RD, Martínez JA, Fiegenbaum M, Reis Gaya A, Pollo Renner JD, Reuter CP, de Moura Valim AR. Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents. International Journal of Environmental Research and Public Health. 2021; 18(18):9797. https://doi.org/10.3390/ijerph18189797

Chicago/Turabian Style

Todendi, Pâmela F., Caroline Brand, João F. de Castro Silveira, Ryan D. Burns, J. A. Martínez, Marilu Fiegenbaum, Anelise Reis Gaya, Jane D. Pollo Renner, Cézane P. Reuter, and Andréia R. de Moura Valim 2021. "Cardiorespiratory Fitness and Muscular Strength Moderates the Relationship between FNDC5 Polymorphism and Adiposity in Children and Adolescents" International Journal of Environmental Research and Public Health 18, no. 18: 9797. https://doi.org/10.3390/ijerph18189797

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