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Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study

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Faculty of Medical Science, Universidad de Santiago de Chile and Neurosurgery Service, Hospital Regional Libertador Bernardo O’Higgins, Rancagua 2820000, Chile
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Hospital Clínico Fusat, Rancagua 2820000, Chile
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Hospital Regional Libertador Bernardo O’Higgins, Rancagua 2820000, Chile
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Public Health Department, Faculty of Medicine, Universidad Católica del Norte, Coquimbo 1780000, Chile
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Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(15), 7722; https://doi.org/10.3390/ijerph18157722
Received: 15 June 2021 / Revised: 15 July 2021 / Accepted: 17 July 2021 / Published: 21 July 2021
(This article belongs to the Section Infectious Disease Epidemiology)
The potentially detrimental effects of the worldwide deficiency of Omega-3 fatty acids on the COVID-19 pandemic have been underestimated. The Omega-3 Index (O3I), clinical variables, biometric indices, and nutritional information were directly determined for 74 patients with severe COVID-19 and 10 healthy quality-control subjects. The relationships between the OI3 and mechanical ventilation (MV) and death were analyzed. Results: Patients with COVID-19 exhibited low O3I (mean: 4.15%; range: 3.06–6.14%)—consistent with insufficient fish and Omega-3 supplement consumption, and markedly lower than the healthy control subjects (mean: 7.84%; range: 4.65–10.71%). Inverse associations were observed between O3I and MV (OR = 0.459; C.I.: 0.211–0.997) and death (OR = 0.28; C.I.: 0.08–0.985) in severe COVID-19, even after adjusting for sex, age, and well-known risk factors. Conclusion: We present preliminary evidence to support the hypothesis that the risk of severe COVID-19 can be stratified by the O3I quartile. Further investigations are needed to assess the value of the O3I as a blood marker for COVID-19. View Full-Text
Keywords: Omega-3 fatty acids; COVID-19; Omega-3 Index; inflammation Omega-3 fatty acids; COVID-19; Omega-3 Index; inflammation
MDPI and ACS Style

Zapata B., R.; Müller, J.M.; Vásquez, J.E.; Ravera, F.; Lago, G.; Cañón, E.; Castañeda, D.; Pradenas, M.; Ramírez-Santana, M. Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study. Int. J. Environ. Res. Public Health 2021, 18, 7722. https://doi.org/10.3390/ijerph18157722

AMA Style

Zapata B. R, Müller JM, Vásquez JE, Ravera F, Lago G, Cañón E, Castañeda D, Pradenas M, Ramírez-Santana M. Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study. International Journal of Environmental Research and Public Health. 2021; 18(15):7722. https://doi.org/10.3390/ijerph18157722

Chicago/Turabian Style

Zapata B., Rodrigo, José Miguel Müller, Juan Enrique Vásquez, Franco Ravera, Gustavo Lago, Eduardo Cañón, Daniella Castañeda, Madelaine Pradenas, and Muriel Ramírez-Santana. 2021. "Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study" International Journal of Environmental Research and Public Health 18, no. 15: 7722. https://doi.org/10.3390/ijerph18157722

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