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Article

Interrupted Time Series Analysis of Changes in Zolpidem Use Due to Media Broadcasts

1
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
2
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea
3
Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea
4
Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon 21983, Korea
5
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea
*
Authors to whom correspondence should be addressed.
Two authors equally contributed as first author to this work.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(10), 5114; https://doi.org/10.3390/ijerph18105114
Received: 29 March 2021 / Revised: 30 April 2021 / Accepted: 9 May 2021 / Published: 12 May 2021
Media has become a major source of information on health and plays a role in the decision-making process on health topics. We aimed to evaluate the association between zolpidem use and media broadcasts that reported the suicide risk. We obtained the data of adult outpatients who have been prescribed zolpidem or other hypnotics from the National Patient Sample database (2015–2017). We evaluated the change in zolpidem or other hypnotic prescription trends based on the prescription rate and average daily prescribed dose before and after July 2016, using interrupted time series analysis. A total of 129,787 adult patients had at least one zolpidem prescription in 3 years. The prescription rate of zolpidem after the broadcast decreased significantly by 0.178% (95% confidence interval (CI): −0.214, −0.142), whereas that of other hypnotic users did not differ from that before the broadcast (−0.020%, 95% CI: −0.088, 0.047). However, the trends in the prescription rate before and after the broadcast did not differ for zolpidem and other hypnotics. Broadcasting medication safety through major public media could have an effect on medication use. After broadcasting about the suicide risk of zolpidem, its overall prescription rate decreased immediately, but the trend was not changed. View Full-Text
Keywords: zolpidem; broadcast; medication safety; interrupted time series analysis zolpidem; broadcast; medication safety; interrupted time series analysis
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MDPI and ACS Style

Yang, B.-R.; Heo, K.-N.; Yu, Y.M.; Yeom, G.-B.; Choi, H.D.; Lee, J.-Y.; Ah, Y.-M. Interrupted Time Series Analysis of Changes in Zolpidem Use Due to Media Broadcasts. Int. J. Environ. Res. Public Health 2021, 18, 5114. https://doi.org/10.3390/ijerph18105114

AMA Style

Yang B-R, Heo K-N, Yu YM, Yeom G-B, Choi HD, Lee J-Y, Ah Y-M. Interrupted Time Series Analysis of Changes in Zolpidem Use Due to Media Broadcasts. International Journal of Environmental Research and Public Health. 2021; 18(10):5114. https://doi.org/10.3390/ijerph18105114

Chicago/Turabian Style

Yang, Bo-Ram, Kyu-Nam Heo, Yun Mi Yu, Ga-Bin Yeom, Hye Duck Choi, Ju-Yeun Lee, and Young-Mi Ah. 2021. "Interrupted Time Series Analysis of Changes in Zolpidem Use Due to Media Broadcasts" International Journal of Environmental Research and Public Health 18, no. 10: 5114. https://doi.org/10.3390/ijerph18105114

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