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Brief Report

Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series

1
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, c/o Neuroradiology Unit, “Bellaria” Hospital, 40139 Bologna, Italy
2
Hyperbaric Centre of Bologna, Quarto Inferiore, 40057 Bologna, Italy
3
Neuroradiology Unit, “Bellaria” Hospital, IRCCS Institute of Neurological Sciences, 40139 Bologna, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(1), 190; https://doi.org/10.3390/ijerph18010190
Received: 6 October 2020 / Revised: 21 December 2020 / Accepted: 24 December 2020 / Published: 29 December 2020
(This article belongs to the Section Environmental Health)
Topics: Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts). Introduction: Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used fMRI technique for this purpose, till now. Methods: All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms). Results: After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas. Conclusions: These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT. View Full-Text
Keywords: HyperBaric Oxygen Therapy (HBOT); chronic cerebral stroke; Blood Oxygenation Level-Dependent (BOLD) signal; functional Magnetic Resonance Imaging (fMRI) HyperBaric Oxygen Therapy (HBOT); chronic cerebral stroke; Blood Oxygenation Level-Dependent (BOLD) signal; functional Magnetic Resonance Imaging (fMRI)
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MDPI and ACS Style

Cevolani, D.; Di Donato, F.; Santarella, L.; Bertossi, S.; Cellerini, M. Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series. Int. J. Environ. Res. Public Health 2021, 18, 190. https://doi.org/10.3390/ijerph18010190

AMA Style

Cevolani D, Di Donato F, Santarella L, Bertossi S, Cellerini M. Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series. International Journal of Environmental Research and Public Health. 2021; 18(1):190. https://doi.org/10.3390/ijerph18010190

Chicago/Turabian Style

Cevolani, Daniela, Ferruccio Di Donato, Luigi Santarella, Simone Bertossi, and Martino Cellerini. 2021. "Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series" International Journal of Environmental Research and Public Health 18, no. 1: 190. https://doi.org/10.3390/ijerph18010190

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