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Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations

1
School of Pharmacy, International Medical University, No. 126 Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Malaysia
2
Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501, USA
3
Infectious Diseases Division, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA
4
Department of Pharmaceutical Technology, International Medical University, No. 126 Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Malaysia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2020, 17(9), 3326; https://doi.org/10.3390/ijerph17093326
Received: 26 March 2020 / Revised: 8 May 2020 / Accepted: 8 May 2020 / Published: 11 May 2020
Hand hygiene is of utmost importance as it may be contaminated easily from direct contact with airborne microorganism droplets from coughs and sneezes. Particularly in situations like pandemic outbreak, it is crucial to interrupt the transmission chain of the virus by the practice of proper hand sanitization. It can be achieved with contact isolation and strict infection control tool like maintaining good hand hygiene in hospital settings and in public. The success of the hand sanitization solely depends on the use of effective hand disinfecting agents formulated in various types and forms such as antimicrobial soaps, water-based or alcohol-based hand sanitizer, with the latter being widely used in hospital settings. To date, most of the effective hand sanitizer products are alcohol-based formulations containing 62%–95% of alcohol as it can denature the proteins of microbes and the ability to inactivate viruses. This systematic review correlated with the data available in Pubmed, and it will investigate the range of available hand sanitizers and their effectiveness as well as the formulation aspects, adverse effects, and recommendations to enhance the formulation efficiency and safety. Further, this article highlights the efficacy of alcohol-based hand sanitizer against the coronavirus. View Full-Text
Keywords: hand sanitizer; hand disinfectants; infection control hand sanitizer; hand disinfectants; infection control
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MDPI and ACS Style

Jing, J.L.J.; Pei Yi, T.; Bose, R.J.C.; McCarthy, J.R.; Tharmalingam, N.; Madheswaran, T. Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations. Int. J. Environ. Res. Public Health 2020, 17, 3326. https://doi.org/10.3390/ijerph17093326

AMA Style

Jing JLJ, Pei Yi T, Bose RJC, McCarthy JR, Tharmalingam N, Madheswaran T. Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations. International Journal of Environmental Research and Public Health. 2020; 17(9):3326. https://doi.org/10.3390/ijerph17093326

Chicago/Turabian Style

Jing, Jane L.J.; Pei Yi, Thong; Bose, Rajendran J.C.; McCarthy, Jason R.; Tharmalingam, Nagendran; Madheswaran, Thiagarajan. 2020. "Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations" Int. J. Environ. Res. Public Health 17, no. 9: 3326. https://doi.org/10.3390/ijerph17093326

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