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Open AccessArticle

Changes of Somatosensory Phenotype in the Course of Disease in Osteoarthritis Patients

1
Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
2
Department of Orthopedics and Trauma Surgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
3
Private Practice for Orthopedics and Trauma Surgery am Arndtplatz, 24116 Kiel, Germany
*
Author to whom correspondence should be addressed.
Equally contributed.
Int. J. Environ. Res. Public Health 2020, 17(9), 3085; https://doi.org/10.3390/ijerph17093085
Received: 27 March 2020 / Revised: 16 April 2020 / Accepted: 22 April 2020 / Published: 29 April 2020
(This article belongs to the Special Issue Chronic Pain and Headache)
To investigate sensory changes, physical function (pF), quality of life (QoL) and pain intensity of patients with osteoarthritis (OA) in the natural course of disease, and patients undergoing total joint replacement therapy (TJR) 31 (20 females, mean age 64.6 ± 10.4 years), patients with OA were investigated with questionnaires and quantitative sensory testing (QST) in the area of referred pain at the thigh at baseline and follow-up 22–49 weeks later; changes were analyzed separately for patients with (n = 13) and without TJR (n = 18). In patients without TJR pain intensity, pF, QoL did not improve, and increased pain sensitivity to cold and a stronger loss of detection were observed. In patients after TJR, however, a reduction in mechanical pain sensitivity and allodynia occurred in accordance with a reduction of pain intensity and improvement of functionality while QoL did not improve. Additionally, an increased sensitivity to heat pain and a more pronounced loss of mechanical detection could be observed in this group. TJR seems to stop peripheral pain input leading to a reduction of pain intensity and central sensitization, but surgery-induced sensory changes such as peripheral sensitization and loss of detection occur. Furthermore, TJR has favorable effects on pain intensity and functionality but not QoL. View Full-Text
Keywords: osteoarthritis; quantitative sensory testing; total joint replacement; somatosensory phenotype; sensitization osteoarthritis; quantitative sensory testing; total joint replacement; somatosensory phenotype; sensitization
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MDPI and ACS Style

Höper, J.; Schraml, L.; Gierthmühlen, J.; Helfert, S.M.; Rehm, S.; Härtig, S.; Schröder, O.; Lankes, M.; Traulsen, F.C.; Seekamp, A.; Baron, R. Changes of Somatosensory Phenotype in the Course of Disease in Osteoarthritis Patients. Int. J. Environ. Res. Public Health 2020, 17, 3085. https://doi.org/10.3390/ijerph17093085

AMA Style

Höper J, Schraml L, Gierthmühlen J, Helfert SM, Rehm S, Härtig S, Schröder O, Lankes M, Traulsen FC, Seekamp A, Baron R. Changes of Somatosensory Phenotype in the Course of Disease in Osteoarthritis Patients. International Journal of Environmental Research and Public Health. 2020; 17(9):3085. https://doi.org/10.3390/ijerph17093085

Chicago/Turabian Style

Höper, Johanna; Schraml, Lara; Gierthmühlen, Janne; Helfert, Stephanie M.; Rehm, Stefanie; Härtig, Susanne; Schröder, Ove; Lankes, Michael; Traulsen, Frieder C.; Seekamp, Andreas; Baron, Ralf. 2020. "Changes of Somatosensory Phenotype in the Course of Disease in Osteoarthritis Patients" Int. J. Environ. Res. Public Health 17, no. 9: 3085. https://doi.org/10.3390/ijerph17093085

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