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Open AccessReview

The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment

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Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo 315100, China
2
Faculty of Science and Engineering, University of Nottingham Malaysia Campus, Selangor 43500, Malaysia
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Ningbo New Materials Institute, University of Nottingham, Ningbo 315042, China
4
Beijing International Center for Mathematical Research, Peking University, Beijing 100871, China
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MITMECHE, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Faculty of Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK
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Key Laboratory for Carbonaceous Wastes Processing and Process Intensification Research of Zhejiang Province, The University of Nottingham Ningbo China, Ningbo 315100, China
*
Author to whom correspondence should be addressed.
Joint first authors.
Int. J. Environ. Res. Public Health 2020, 17(7), 2323; https://doi.org/10.3390/ijerph17072323
Received: 14 February 2020 / Revised: 5 March 2020 / Accepted: 25 March 2020 / Published: 30 March 2020
The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV) outbreak has engulfed an unprepared world amidst a festive season. The zoonotic SARS-CoV-2, believed to have originated from infected bats, is the seventh member of enveloped RNA coronavirus. Specifically, the overall genome sequence of the SARS-CoV-2 is 96.2% identical to that of bat coronavirus termed BatCoV RaTG13. Although the current mortality rate of 2% is significantly lower than that of SARS (9.6%) and Middle East respiratory syndrome (MERS) (35%), SARS-CoV-2 is highly contagious and transmissible from human to human with an incubation period of up to 24 days. Some statistical studies have shown that, on average, one infected patient may lead to a subsequent 5.7 confirmed cases. Since the first reported case of coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 on December 1, 2019, in Wuhan, China, there has been a total of 60,412 confirmed cases with 1370 fatalities reported in 25 different countries as of February 13, 2020. The outbreak has led to severe impacts on social health and the economy at various levels. This paper is a review of the significant, continuous global effort that was made to respond to the outbreak in the first 75 days. Although no vaccines have been discovered yet, a series of containment measures have been implemented by various governments, especially in China, in the effort to prevent further outbreak, whilst various medical treatment approaches have been used to successfully treat infected patients. On the basis of current studies, it would appear that the combined antiviral treatment has shown the highest success rate. This review aims to critically summarize the most recent advances in understanding the coronavirus, as well as the strategies in prevention and treatment. View Full-Text
Keywords: coronavirus; SARS-CoV-2; COVID-19; coronavirus-infected pneumonia; novel coronavirus pneumonia; zoonotic pathogen coronavirus; SARS-CoV-2; COVID-19; coronavirus-infected pneumonia; novel coronavirus pneumonia; zoonotic pathogen
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MDPI and ACS Style

Yan, Y.; Shin, W.I.; Pang, Y.X.; Meng, Y.; Lai, J.; You, C.; Zhao, H.; Lester, E.; Wu, T.; Pang, C.H. The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment. Int. J. Environ. Res. Public Health 2020, 17, 2323. https://doi.org/10.3390/ijerph17072323

AMA Style

Yan Y, Shin WI, Pang YX, Meng Y, Lai J, You C, Zhao H, Lester E, Wu T, Pang CH. The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment. International Journal of Environmental Research and Public Health. 2020; 17(7):2323. https://doi.org/10.3390/ijerph17072323

Chicago/Turabian Style

Yan, Yuxin; Shin, Woo I.; Pang, Yoong X.; Meng, Yang; Lai, Jianchen; You, Chong; Zhao, Haitao; Lester, Edward; Wu, Tao; Pang, Cheng H. 2020. "The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment" Int. J. Environ. Res. Public Health 17, no. 7: 2323. https://doi.org/10.3390/ijerph17072323

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