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Open AccessArticle

Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

1
Department of Oral Implantology, Istanbul University Faculty of Dentistry, Istanbul, 34093 Fatih, Turkey
2
Pathology and Oncology Cytology Department of Institute of Oncology, Istanbul University, 34093 Fatih, Turkey
3
Department of Otolaryngology, Head and Neck and Maxilllofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 5219100 Ramat Aviv, Israel
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(6), 1918; https://doi.org/10.3390/ijerph17061918
Received: 16 December 2019 / Revised: 3 March 2020 / Accepted: 4 March 2020 / Published: 15 March 2020
(This article belongs to the Special Issue Digital Dentistry for Oral Health)
This randomized controlled clinical trial evaluated the effect of mineralized plasmatic matrix (MPM), comprised of synthetic graft and platelet concentrates, on new bone formation and volume stability over time in maxillary sinus lifting (MSL). Unilateral MSL was performed in 20 patients with either beta-tricalcium phosphate (β-TCP) or MPM grafts (10 sinuses each). Six months postsurgery, specimens were obtained with a trephine bur prior to implant placement in 39 cases. Volumetric changes in sinus augmentation were analyzed between 1 week (T-I) and 6 months (T-II) postsurgery. Histomorphometric and histological analyses of biopsy samples revealed mean new bone percentages of 35.40% ± 9.09% and 26.92% ± 7.26% and residual graft particle areas of 23.13% ± 6.16% and 32.25% ± 8.48% in the MPM and β-TCP groups, respectively (p < 0.05). The mean soft-tissue areas in the MPM and β-TCP groups were 41.48% ± 8.41% and 40.83% ± 8.86%, respectively (p > 0.05). Graft reductions between baseline and 6-months postprocedure in the β-TCP and MPM groups were 17.12% ± 13.55% and 14.41% ± 12.87%, respectively, with significant graft volume reduction observed in both groups (p < 0.05) while there is no significant difference between MPM and β-TCP groups (p > 0.05). Thus, MPM, representing growth factors in a fibrin network, increases new bone formation and has acceptable volume stability in MSL procedures View Full-Text
Keywords: beta-tricalcium phosphate; histomorphometry; maxillary sinus lifting; mineralized plasmatic matrix; volume change beta-tricalcium phosphate; histomorphometry; maxillary sinus lifting; mineralized plasmatic matrix; volume change
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MDPI and ACS Style

Cinar, I.C.; Gultekin, B.A.; Saglanmak, A.; Yalcin, S.; Olgac, V.; Mijiritsky, E. Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation. Int. J. Environ. Res. Public Health 2020, 17, 1918. https://doi.org/10.3390/ijerph17061918

AMA Style

Cinar IC, Gultekin BA, Saglanmak A, Yalcin S, Olgac V, Mijiritsky E. Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation. International Journal of Environmental Research and Public Health. 2020; 17(6):1918. https://doi.org/10.3390/ijerph17061918

Chicago/Turabian Style

Cinar, Ihsan C.; Gultekin, Bahattin A.; Saglanmak, Alper; Yalcin, Serdar; Olgac, Vakur; Mijiritsky, Eitan. 2020. "Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation" Int. J. Environ. Res. Public Health 17, no. 6: 1918. https://doi.org/10.3390/ijerph17061918

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