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Article

The Association between Metabolically Healthy Obesity, Cardiovascular Disease, and All-Cause Mortality Risk in Asia: A Systematic Review and Meta-Analysis

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Department of Family Medicine, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan
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Department of Medicine, MacKay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City 25245, Taiwan
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Hospice and Palliative Care Center, MacKay Memorial Hospital, No. 45, Minsheng Rd., Tamsui District, New Taipei City 25160, Taiwan
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Post Graduate Year, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan
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Department of Family Medicine, Hsinchu MacKay Memorial Hospital, No. 690, Section 2, Guangfu Road, East District, Hsinchu City 30071, Taiwan
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MacKay Junior College of Medicine, Nursing, and Management, No. 92, Shengjing Rd., Beitou Dist., Taipei City 11260, Taiwan
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Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 30071, Taiwan
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Department of Medical Library, MacKay Memorial Hospital, No. 45, Minsheng Rd., Tamsui District, New Taipei City 25160, Taiwan
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Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 10002, Taiwan
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Institute of Epidemiology and Preventive Medicine, National Taiwan University, Room 517, No.17, Xu-Zhou Rd., Taipei City 10055, Taiwan
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Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(4), 1320; https://doi.org/10.3390/ijerph17041320
Received: 19 December 2019 / Revised: 9 February 2020 / Accepted: 14 February 2020 / Published: 19 February 2020
(This article belongs to the Special Issue Big Data, Decision Models, and Public Health)
We investigated the association among metabolically healthy obesity (MHO), cardiovascular disease (CVD)risk, and all-cause mortality in the Asian population. We searched databases from inception to 16 November, 2019 and pooled data using a random-effects model. Subgroup analysis was conducted according to the following comparison groups: MHNW (without overweight or underweight participants) and MHNO (non-obese, including overweight and underweight participants). Nineteen studies were included. The mean Newcastle–Ottawa Scale score was 7.8. Participants with MHO had a significantly higher CVD risk (odds ratio (OR) = 1.36, 95% confidence interval (CI) = 1.13–1.63) and significantly lower risk of all-cause mortality (OR = 0.88, 95% CI = 0.78–1.00) than the comparison group. Subgroup analyses revealed participants with MHO had a significantly higher CVD risk than MHNW participants (OR = 1.61; 95% CI = 1.24–2.08; I2 = 73%), but there was no significant difference compared with MHNO participants (OR, 1.04; 95% CI, 0.80–1.36; I2 = 68%). Participants with MHO had a significantly lower risk of all-cause mortality (OR = 0.83; 95% CI = 0.78–0.88; I2 = 9%) than MHNO participants, but a borderline significantly higher risk of all-cause mortality than MHNW participants (OR = 1.30; 95% CI = 0.99–1.72; I2 = 0%). The CVD risk and all-cause mortality of the MHO group changed depending on the control group. Thus, future studies should select control groups carefully. View Full-Text
Keywords: metabolically healthy obesity; cardiovascular disease; all-cause mortality; Asia; meta-analysis metabolically healthy obesity; cardiovascular disease; all-cause mortality; Asia; meta-analysis
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MDPI and ACS Style

Huang, M.-Y.; Wang, M.-Y.; Lin, Y.-S.; Lin, C.-J.; Lo, K.; Chang, I.-J.; Cheng, T.-Y.; Tsai, S.-Y.; Chen, H.-H.; Lin, C.-Y.; Liu, S.J.; Chien, K.-L.; Yeh, T.-L. The Association between Metabolically Healthy Obesity, Cardiovascular Disease, and All-Cause Mortality Risk in Asia: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2020, 17, 1320. https://doi.org/10.3390/ijerph17041320

AMA Style

Huang M-Y, Wang M-Y, Lin Y-S, Lin C-J, Lo K, Chang I-J, Cheng T-Y, Tsai S-Y, Chen H-H, Lin C-Y, Liu SJ, Chien K-L, Yeh T-L. The Association between Metabolically Healthy Obesity, Cardiovascular Disease, and All-Cause Mortality Risk in Asia: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2020; 17(4):1320. https://doi.org/10.3390/ijerph17041320

Chicago/Turabian Style

Huang, Ming-Yuan, Mu-Yi Wang, Yu-Sheng Lin, Chien-Ju Lin, Kai Lo, I-Jen Chang, Ting-Yao Cheng, Szu-Ying Tsai, Hsin-Hao Chen, Chien-Yu Lin, Shu J. Liu, Kuo-Liong Chien, and Tzu-Lin Yeh. 2020. "The Association between Metabolically Healthy Obesity, Cardiovascular Disease, and All-Cause Mortality Risk in Asia: A Systematic Review and Meta-Analysis" International Journal of Environmental Research and Public Health 17, no. 4: 1320. https://doi.org/10.3390/ijerph17041320

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