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Article

Effect of Lambdacyhalothrin on Locomotor Activity, Memory, Selected Biochemical Parameters, Tumor Necrosis Factor α, and Interleukin 1ß in a Mouse Model

1
Chair and Department of Hygiene, Medical University of Lublin, Aleje Racławickie 1, 20-059 Lublin, Poland
2
Department of Otolaryngology and Laryngological Oncology, Independent Public Clinical Hospital No. 4 in Lublin, 20-059 Lublin, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(24), 9240; https://doi.org/10.3390/ijerph17249240
Received: 18 November 2020 / Revised: 3 December 2020 / Accepted: 9 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Current Insights into Immunotoxicology)
Background: Pyrethroids are synthetic insecticides used for plant protection. They are synthetic analogues of pyrethrins. Lambdacyhalothrin (LCH) is a type II pyrethroid used for wheat, potato, corn farming, and malaria control. There are data that pyrethroids may cause neurotoxicity, nephrotoxicity, hepatotoxicity, and immunotoxicity in non-target organisms. Methods: The experiment was carried on 32 Albino Swiss mice (16 females and 16 males). The animals were divided into four groups. Controls received canola oil; the rest received LCH orally in oil at a dose of 2 mg/kg bw for 7 days. Memory retention was assessed in a passive avoidance task on day 2 and 7, and spatial memory and motor activity in a Y-maze on day 1 and 7. Blood morphology, biochemical tests, tumor necrosis factor α, and interleukin 1ß were measured. Results: Decreased white blood cell count and red blood cell count, increased creatinine, and increased kidney and liver mass were observed in groups exposed to LCH. In LCH-exposed males’ kidneys and livers, interleukin 1ß was significantly elevated, and it was correlated with creatinine concentration. Conclusions: Subacute poisoning with a low dose of LCH does not significantly affect memory nor locomotor activity but increases proinflammatory interleukin 1ß in male livers and kidneys and reduces white and red blood cell counts. View Full-Text
Keywords: pyrethroids; lambdacyhalothrin; nephrotoxicity; hepatotoxicity; immunotoxicity pyrethroids; lambdacyhalothrin; nephrotoxicity; hepatotoxicity; immunotoxicity
MDPI and ACS Style

Nieradko-Iwanicka, B.; Konopelko, M. Effect of Lambdacyhalothrin on Locomotor Activity, Memory, Selected Biochemical Parameters, Tumor Necrosis Factor α, and Interleukin 1ß in a Mouse Model. Int. J. Environ. Res. Public Health 2020, 17, 9240. https://doi.org/10.3390/ijerph17249240

AMA Style

Nieradko-Iwanicka B, Konopelko M. Effect of Lambdacyhalothrin on Locomotor Activity, Memory, Selected Biochemical Parameters, Tumor Necrosis Factor α, and Interleukin 1ß in a Mouse Model. International Journal of Environmental Research and Public Health. 2020; 17(24):9240. https://doi.org/10.3390/ijerph17249240

Chicago/Turabian Style

Nieradko-Iwanicka, Barbara, and Michał Konopelko. 2020. "Effect of Lambdacyhalothrin on Locomotor Activity, Memory, Selected Biochemical Parameters, Tumor Necrosis Factor α, and Interleukin 1ß in a Mouse Model" International Journal of Environmental Research and Public Health 17, no. 24: 9240. https://doi.org/10.3390/ijerph17249240

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