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Open AccessArticle

Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort

1
Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China
2
Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China
*
Author to whom correspondence should be addressed.
Shengkui Zhang and Yongbin Wang contributed equally to this paper.
Int. J. Environ. Res. Public Health 2020, 17(23), 9035; https://doi.org/10.3390/ijerph17239035
Received: 30 October 2020 / Revised: 24 November 2020 / Accepted: 1 December 2020 / Published: 4 December 2020
The misalignment between the circadian clock and behavioral cycles has been implicated in pathogenesis of many diseases. The main purpose of this study is to examine the association between rotating night shift work, exposure to light at night, and glomerular filtration rate among steelworkers in north China. A total of 6869 steelworkers, aged 22 to 60 years, were included in this study. Multivariable logistic regression was used to examine the association between night shift work, the brightness of bedroom ambient light at night (LAN), and estimated glomerular filtration rate (eGFR), with adjustment for potential confounders. Mediation analysis was performed to examine the mediation effect of potential mediators on the association of duration of night shifts and eGFR. Long duration of night shift work (≥29 years) had elevated odds of decreased eGFR (≤89 mL/min/1.73 m2) (odds ratio (OR), 1.37, 95% confidence interval (CI) 1.09–1.73) compared with day work after adjustment for potential confounders. The association between duration of night shifts and eGFR (continuous) was partially modified by diastolic blood pressure (average causal mediation effect (ACME), –0.077, 95% CI –0.134 to −0.030, p < 0.001). No significant associations were observed among the different brightness of bedroom ambient light levels: middle level (OR, 0.90, 95% CI 0.77–1.05), lightest level (OR, 0.94, 95% CI 0.75–1.18), and decreased eGFR compared with the darkest level. Long-term night-shift work, rather than the brightness of bedroom ambient LAN, is associated with early stage of renal dysfunction in steelworkers, and blood pressure may mediate the relationship between night shift work and decreased eGFR. View Full-Text
Keywords: renal function; light at night; night shift work renal function; light at night; night shift work
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MDPI and ACS Style

Zhang, S.; Wang, Y.; Zhu, Y.; Li, X.; Song, Y.; Yuan, J. Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort. Int. J. Environ. Res. Public Health 2020, 17, 9035. https://doi.org/10.3390/ijerph17239035

AMA Style

Zhang S, Wang Y, Zhu Y, Li X, Song Y, Yuan J. Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort. International Journal of Environmental Research and Public Health. 2020; 17(23):9035. https://doi.org/10.3390/ijerph17239035

Chicago/Turabian Style

Zhang, Shengkui; Wang, Yongbin; Zhu, Ying; Li, Xiaoming; Song, Yang; Yuan, Juxiang. 2020. "Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort" Int. J. Environ. Res. Public Health 17, no. 23: 9035. https://doi.org/10.3390/ijerph17239035

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