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Open AccessArticle

Effect of Chinese Propolis as an Intracanal Medicament on Post-Operative Endodontic Pain: A Double-Blind Randomized Controlled Trial

1
Department of Operative Dentistry & Endodontics, Dow International Dental College, Dow University of Health Sciences, Karachi 74200, Pakistan
2
Liaquat College of Medicine and Dentistry, Operative Dentistry Department, Karachi 75290, Pakistan
3
Department of Operative Dentistry & Endodontics, Dr. Ishrat-ul-ibad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi 72400, Pakistan
4
School of Public Health, Dow University of Health Sciences, Karachi 74200, Pakistan
5
Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al Ahsa 31982, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(2), 445; https://doi.org/10.3390/ijerph17020445
Received: 19 December 2019 / Revised: 6 January 2020 / Accepted: 7 January 2020 / Published: 9 January 2020
(This article belongs to the Special Issue Oral Health and Diseases)
Propolis is a potent anti-microbial and natural anti-inflammatory by-product obtained from the beehive. Studies have demonstrated the superior biocompatibility and anti-microbial properties of propolis as compared to calcium hydroxide. However, its effect on postoperative endodontic pain is unknown. Therefore, this study aimed to investigate the impact of Chinese propolis paste as an intracanal medicament on postoperative endodontic pain intensities compared with calcium hydroxide (control) at different time intervals in necrotic teeth with periapical radiolucency. Eighty patients with single-rooted necrotic teeth with visible periapical radiolucency were recruited and randomly allocated to either the calcium hydroxide or propolis groups. After chemo-mechanical preparation and intracanal medicament insertion, patients were given the VAS (visual analogue scale) to record pain scores. Inter-group data were compared and analyzed using two-way repeated measure ANOVA (Bonferroni test). A p-value of < 0.025 was considered significant. In total, >78% of the patients experienced no or only mild post-operative pain in both the groups at all time intervals, without any significant difference in pain scores between the two groups (p > 0.025). An overall flare-up rate of 14.8% was found. The results suggest that either of these medicaments can be used as an inter-appointment medication for the prevention of postoperative pain in necrotic cases. View Full-Text
Keywords: calcium hydroxide; propolis; postoperative pain; natural product; clinical trial calcium hydroxide; propolis; postoperative pain; natural product; clinical trial
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MDPI and ACS Style

Shabbir, J.; Qazi, F.; Farooqui, W.; Ahmed, S.; Zehra, T.; Khurshid, Z. Effect of Chinese Propolis as an Intracanal Medicament on Post-Operative Endodontic Pain: A Double-Blind Randomized Controlled Trial. Int. J. Environ. Res. Public Health 2020, 17, 445.

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