Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Studies
2.2. Measurements of Body and SG Weights, Salivary Flow Rates, and Lag Times
2.3. SPECT Image Analysis
2.4. Histopathology
2.5. Immunohistochemistry
2.6. Detection of Amylase Activity and Expression in Saliva
2.7. Detection of Apoptosis and Related Proteins
2.8. Western Blotting
2.9. Statistical Analysis
3. Results
3.1. Preventive Effect of KGF-1 on RI Induced Body and SG Weight Losses
3.2. Protective Effect of KGF-1 on RI-Induced SG Dysfunction
3.3. Enhanced SG Secretory Function by KGF-1
3.4. Salivary Cell Protective Effect of KGF-1
3.5. Anti-Apoptotic Effect of KGF-1 in SGs
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Kim, J.M.; Choi, M.E.; Kim, S.-K.; Kim, J.W.; Kim, Y.-M.; Choi, J.-S. Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice. Int. J. Environ. Res. Public Health 2020, 17, 6322. https://doi.org/10.3390/ijerph17176322
Kim JM, Choi ME, Kim S-K, Kim JW, Kim Y-M, Choi J-S. Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice. International Journal of Environmental Research and Public Health. 2020; 17(17):6322. https://doi.org/10.3390/ijerph17176322
Chicago/Turabian StyleKim, Jeong Mi, Mi Eun Choi, Seok-Ki Kim, Ji Won Kim, Young-Mo Kim, and Jeong-Seok Choi. 2020. "Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice" International Journal of Environmental Research and Public Health 17, no. 17: 6322. https://doi.org/10.3390/ijerph17176322