On the Optimal Indoor Air Conditions for SARS-CoV-2 Inactivation. An Enthalpy-Based Approach
Abstract
:1. Introduction
2. Material and Methods
2.1. Background
2.2. Literature Synopsis on Contributing Factors
2.2.1. Virus Survival and Transmission
- (i)
- RH may act at the level of the environment. Since a higher humidity implies a slower evaporation from large droplets, the faster evaporation occurring at low RHs would more rapidly change these into droplet nuclei (<5 micron), quickly enough before they fall. Thus, people inhale fewer droplets at a higher RH.
- (ii)
- RH may act at the level of the host. The activity of nasal mucosa strongly depends on the humidity and temperature of the inhaled air, on the exposure time, and on the health of the individual [38]. Lower or higher RH, compared to medium RH values, will alter the mucous viscosity and mucociliary activity. In general, extremely low humidities are reported as enabling the viruses’ settlement in human hosts. Moreover, the dryness of the respiratory epithelium, which plays an important role via the evaporation of water from its surface (desiccation), may increase bacterial adherence and allows for greater penetration of foreign species, such as particles [39]. The upper airways need to achieve moisture neutrality and maximum mucociliary transport as fast as possible. However, the corresponding saccharin mucociliary clearance time in the upper airways is a function of RH [9]. This leads to a recommendation of RH > 30% to avoid “dry eyes”, and RH > 10% to avoid nasal dryness.
- (iii)
- RH may act at the level of the virus particle, affecting its virulence. Virus stability in air may directly affect virus transmission, because virus particles need to remain viable long enough after being expelled from the host to be taken up by a novel host (indirect transmission) [3].
2.2.2. Indoor Environment Vulnerabilities
2.3. Challenging Trade-Off
2.4. A Parameter for Correlating Literature Data
3. Results
4. Discussion
4.1. Obtained Space of Viable Solutions—Preliminary Recommendations
4.2. HVAC Plants Optimal Setting
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Temperature [°C] | RH (%) | VLS1h | Virus Type | AH [kgvap/kgdry-air] | H [kJ/kgdry-air] | |
---|---|---|---|---|---|---|
Pyankov et al. [77]-2018 | 25 | 79 | 0.634 | HCoV-EMC | 0.0158 | 65.32 |
Pyankov et al. [77]-2018 | 38 | 24 | 0.046 | HCoV-EMC | 0.0099 | 63.77 |
Van Doremalen et al. [2]-2020 | 22 | 65 | 0.300 | SARS-CoV-2 | 0.0107 | 49.44 |
Van Doremalen et al. [2]-2020 | 22 | 65 | 0.293 | SARS-CoV-1 | 0.0107 | 49.44 |
Van Doremalen et al. [76]-2013 | 20 | 40 | 0.930 | HCoV-EMC | 0.0058 | 34.84 |
Van Doremalen et al. [76]-2013 | 20 | 70 | 0.110 | HCoV-EMC | 0.0102 | 46.06 |
Prussin et al. [72]-2018 | 22 | 33 | 0.970 | Phi6 | 0.0054 | 35.88 |
Prussin et al. [72]-2018 | 22 | 43 | 0.820 | Phi6 | 0.0071 | 40.09 |
Prussin et al. [72]-2018 | 22 | 55 | 0.360 | Phi6 | 0.0091 | 45.18 |
Prussin et al. [72]-2018 | 22 | 75 | 0.010 | Phi6 | 0.0124 | 53.72 |
Prussin et al. [72]-2018 | 22 | 85 | 0.050 | Phi6 | 0.0141 | 58.03 |
Prussin et al. [72]-2018 | 22 | 98 | 0.640 | Phi6 | 0.0163 | 63.66 |
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Spena, A.; Palombi, L.; Corcione, M.; Carestia, M.; Spena, V.A. On the Optimal Indoor Air Conditions for SARS-CoV-2 Inactivation. An Enthalpy-Based Approach. Int. J. Environ. Res. Public Health 2020, 17, 6083. https://doi.org/10.3390/ijerph17176083
Spena A, Palombi L, Corcione M, Carestia M, Spena VA. On the Optimal Indoor Air Conditions for SARS-CoV-2 Inactivation. An Enthalpy-Based Approach. International Journal of Environmental Research and Public Health. 2020; 17(17):6083. https://doi.org/10.3390/ijerph17176083
Chicago/Turabian StyleSpena, Angelo, Leonardo Palombi, Massimo Corcione, Mariachiara Carestia, and Vincenzo Andrea Spena. 2020. "On the Optimal Indoor Air Conditions for SARS-CoV-2 Inactivation. An Enthalpy-Based Approach" International Journal of Environmental Research and Public Health 17, no. 17: 6083. https://doi.org/10.3390/ijerph17176083