Next Article in Journal
Development of the Hearing Rehabilitation for Older Adults (HeRO) Healthcare Mobile Application and Its Likely Utility for Elderly Users
Next Article in Special Issue
Clinical Presentation of COVID-19: Case Series and Review of the Literature
Previous Article in Journal
Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women
Open AccessReview

COVID-19: Time for Post-Exposure Prophylaxis?

Department of Clinical Medicine and Surgery–Section of Infectious Diseases, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
UNESCO Chair for Health Education and Sustainable Development, University of Naples Federico II, 80131 Naples, Italy
Section of Endocrinology and Metabolic Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(11), 3997;
Received: 27 May 2020 / Accepted: 2 June 2020 / Published: 4 June 2020
(This article belongs to the Special Issue COVID-19: Prevention, Diagnosis, Therapy and Follow Up)
From a healthcare perspective, infection due to the novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and the ensuing syndrome called COVID-19 (coronavirus disease 2019) represents the biggest challenge the world has faced in several decades. Particularly worrisome are the high contagiousness of the virus and the saturation of hospitals’ capacity due to overwhelming caseloads. Non-pharmaceutical interventions such as quarantine and inter-personal distancing are crucial to limiting the spread of the virus in the general population, but more tailored interventions may be needed at an individual level on a case-by-case basis. In this perspective, the most insidious situation is when an individual has contact with a contagious subject without adequate protection. If rapidly recognized afterwards, this occurrence may be promptly addressed through a post-exposure chemoprophylaxis (PEP) with antiviral drugs. This strategy has been implemented for other respiratory viruses (influenza above all) and was successfully used in South Korea among healthcare workers against the Middle East respiratory syndrome (MERS) coronavirus, by providing people who were exposed to high-risk contacts with lopinavir-ritonavir plus ribavirin. Initial experiences with the use of hydroxychloroquine to prevent COVID-19 also seem promising. Post-exposure chemoprophylaxis might help mitigate the spread of SARS-CoV-2 in the current phase of the COVID-19 pandemic. View Full-Text
Keywords: COVID-19; post-exposure; healthcare; prophylaxis COVID-19; post-exposure; healthcare; prophylaxis
MDPI and ACS Style

Gentile, I.; Maraolo, A.E.; Piscitelli, P.; Colao, A. COVID-19: Time for Post-Exposure Prophylaxis? Int. J. Environ. Res. Public Health 2020, 17, 3997.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop