Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People
Abstract
:1. Introduction
- Assessment of the relationship between cognitive, emotional and functional skills and lifestyle versus the level of the hormone melatonin in elderly people and senile people.
- Assessment of the relationship between cognitive, emotional and functional skills and lifestyle versus the level of pro-inflammatory cytokine interleukin-6 (IL-6) in elderly people and senile people.
2. Materials and Methods
2.1. Study Design
2.2. Procedure
2.3. Ethical Considerations
2.4. Sampling
2.5. Methods, Techniques and Research Tools
2.6. Biochemical Blood Test
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
- The inflammatory marker IL-6 in blood plasma may not be useful in determining cognitive and emotional skills impairment or the intensity of health behaviors among elderly people (60–75 years), both active and requiring constant medical care. It can be partially treated as a predictive factor of functional skills, especially for people over 75 years of age.
- Melatonin can be used in the process of recognizing cognitive skill impairment in elderly people (60–75 years of age) who do not require constant medical care. It can also be used to recognize the functional and emotional skill impairment in senile people who are active and do not require hospitalization or medical support.
- There is a need for further research among older people in more centers in Poland. It also seems extremely important to pay attention to cultural diversity and diet, as well as intensity and type of physical activity of the surveyed people in the future.
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Parameters | The Study Group (N = 66) n/% | The Comparative Group (N = 55) n/% | p * | |
---|---|---|---|---|
Gender | Female | 48/72.73 | 49/89.09 | p = 0.044 |
Male | 18/27.27 | 6/10.91 | ||
Age | 60–65 years old | 3/4.55 | 17/30.91 | p < 0.001 |
66–70 years old | 13/19.70 | 16/29.09 | ||
71–75 years old | 6/9.09 | 11/20.00 | ||
76–80 years old | 15/22.73 | 3/5.45 | ||
81–85 years old | 15/22.73 | 6/10.91 | ||
86–90 years old | 11/16.67 | 2/3.64 | ||
Over 90 years old | 3/4.55 | 0/0.00 | ||
Places of residence | Village | 5/7.58 | 5/9.09 | p = 0.639 |
Town (≤50 thousand people) | 1/1.52 | 0/0.00 | ||
Town (50–100 thousand people) | 3/4.55 | 5/9.09 | ||
Big city (>100 thousand people) | 57/86.36 | 45/81.82 |
Research Tools | Study Group (N = 66) | Comparative Group (N = 55) | p * | |
---|---|---|---|---|
Barthel scale | X ± SD | 40.3 ± 29.39 | 98.09 ± 3.4 | p < 0.001 |
Me | 35 | 100 | ||
quartiles | 20–40 | 95–100 | ||
IADL | X ± SD | 14.71 ± 4.37 | 23.65 ± 1.02 | p < 0.001 |
Me | 13 | 24 | ||
quartiles | 12–17 | 24–24 | ||
MMSE | X ± SD | 22.74 ± 3.35 | 27.53 ± 2.69 | p < 0.001 |
Me | 22 | 28 | ||
quartiles | 20–25 | 26–30 | ||
LOT-R | X ± SD | 14.76 ± 5.31 | 15.82 ± 3.19 | p = 0.362 |
Me | 14 | 15 | ||
quartiles | 12–19 | 13–18 | ||
Total score of IHB | X ± SD | 86.03 ± 16.93 | 95.44 ± 12.82 | p = 0.002 |
Me | 89.5 | 97 | ||
quartiles | 75.5–98.75 | 88–103.5 | ||
IHB: Proper eating habits | X ± SD | 3.33 ± 0.96 | 3.87 ± 0.81 | p = 0.002 |
Me | 3.5 | 4 | ||
quartiles | 2.5–4 | 3.42–4.42 | ||
IHB: Preventive behaviors | X ± SD | 3.43 ± 0.8 | 4.15 ± 0.72 | p < 0.001 |
Me | 3.5 | 4.33 | ||
quartiles | 3–4 | 3.92–4.67 | ||
IHB: Positive mental attitude | X ± SD | 3.66 ± 0.89 | 4.04 ± 0.57 | p = 0.038 |
Me | 3.83 | 4 | ||
quartiles | 3.04–4.33 | 3.67–4.5 | ||
IHB: Health practices | X ± SD | 3.91 ± 0.7 | 3.85 ± 0.68 | p = 0.472 |
Me | 4 | 4 | ||
quartiles | 3.67–4.33 | 3.42–4.33 |
Parameters | Study Group (N = 66) | Comparative Group (N = 55) | p * | |
---|---|---|---|---|
Interleukin-6 [pg/L] | X ± SD | 22.29 ± 36.52 | 17.07 ± 24.16 | p = 0.284 |
Me | 9.86 | 8.24 | ||
quartiles | 5.43–20.11 | 3.38–20.32 | ||
Melatonin [ng/L] | X ± SD | 436.85 ± 336.05 | 471.24 ± 364.67 | p = 0.893 |
Me | 319.75 | 308.62 | ||
quartiles | 225.48–543.09 | 212.28–675.26 |
Research Tools/Parameters | Study Group (N = 66) n/% | Comparative Group (N = 55) n/% | |
---|---|---|---|
Barthel scale | “Severe” health condition | 20/30.30 | 0/0.00 |
“Medium level” health condition | 33/50.00 | 1/1.82 | |
“Mild” health condition | 13/19.70 | 54/98.18 | |
MMSE | No cognitive impairment | 11/16.67 | 39/70.91 |
Cognitive impairment without dementia | 16/24.24 | 12/21.82 | |
Light degree of dementia | 39/59.09 | 4/7.27 | |
LOT-R | Low | 22/33.33 | 8/14.55 |
Medium | 15/22.73 | 24/43.64 | |
High | 29/43.94 | 23/41.82 | |
IHB | Low | 17/25.76 | 5/9.09 |
Medium | 16/24.24 | 13/23.64 | |
High | 33/50.00 | 37/67.27 |
Research Tools | Correlation (Spearman Rank Coefficient) | |||
---|---|---|---|---|
Interleukin-6 | Melatonin | |||
Barthel scale | 0.292 | p = 0.188 | 0.059 | p = 0.805 |
IADL | 0.245 | p = 0.272 | 0.115 | p = 0.631 |
MMSE | −0.142 | p = 0.527 | −0.166 | p = 0.485 |
LOT-R | −0.113 | p = 0.618 | −0.186 | p = 0.433 |
Total score of IHB | 0.26 | p = 0.242 | −0.087 | p = 0.716 |
IHB: Proper eating habits | 0.147 | p = 0.515 | 0.131 | p = 0.581 |
IHB: Preventive behaviors | 0.099 | p = 0.66 | −0.063 | p = 0.793 |
IHB: Positive mental attitude | 0.111 | p = 0.623 | −0.176 | p = 0.459 |
IHB: Health practices | 0.251 | p = 0.259 | −0.090 | p = 0.705 |
Research Tools | Correlation (Spearman Rank Coefficient) | |||
---|---|---|---|---|
Interleukin-6 | Melatonin | |||
Barthel scale | −0.124 | p = 0.424 | −0.205 | p = 0.205 |
IADL | 0.06 | p = 0.697 | −0.227 | p = 0.160 |
MMSE | −0.089 | p = 0.564 | −0.328 | p = 0.039 |
LOT-R | 0.258 | p = 0.091 | −0.255 | p = 0.113 |
Total score of IHB | −0.081 | p = 0.599 | −0.096 | p = 0.558 |
IHB: Proper eating habits | −0.124 | p = 0.424 | −0.025 | p = 0.876 |
IHB: Preventive behaviors | 0.149 | p = 0.333 | −0.282 | p = 0.077 |
IHB: Positive mental attitude | −0.048 | p = 0.758 | −0.011 | p = 0.945 |
IHB: Health practices | −0.165 | p = 0.285 | −0.008 | p = 0.960 |
Research Tools | Correlation (Spearman Rank Coefficient) | |||
---|---|---|---|---|
Interleukin-6 | Melatonin | |||
Barthel scale | −0.183 | p = 0.235 | −0.118 | p = 0.463 |
IADL | −0.331 | p = 0.028 | −0.042 | p = 0.795 |
MMSE | −0.202 | p = 0.187 | −0.275 | p = 0.082 |
LOT-R | −0.154 | p = 0.319 | −0.014 | p = 0.929 |
Total score of IHB | −0.033 | p = 0.832 | −0.276 | p = 0.081 |
IHB: Proper eating habits | 0.085 | p = 0.582 | −0.373 | p = 0.016 |
IHB: Preventive behaviors | −0.027 | p = 0.863 | −0.246 | p = 0.121 |
IHB: Positive mental attitude | −0.108 | p = 0.485 | −0.054 | p = 0.738 |
IHB: Health practices | −0.082 | p = 0.596 | −0.146 | p = 0.363 |
Research Tools | Correlation (Spearman Rank Coefficient) | |||
---|---|---|---|---|
Interleukin-6 | Melatonin | |||
Barthel scale | −0.306 | p = 0.359 | 0.663 | p = 0.026 |
IADL | −0.724 | p = 0.012 | 0.613 | p = 0.045 |
MMSE | 0.433 | p = 0.183 | 0.284 | p = 0.398 |
LOT-R | −0.035 | p = 0.919 | 0.651 | p = 0.030 |
Total score of IHB | −0.174 | p = 0.610 | 0.064 | p = 0.852 |
IHB: Proper eating habits | −0.461 | p = 0.154 | −0.181 | p = 0.594 |
IHB: Preventive behaviors | −0.253 | p = 0.452 | −0.110 | p = 0.747 |
IHB: Positive mental attitude | 0.266 | p = 0.429 | 0.476 | p = 0.139 |
IHB: Health practices | −0.169 | p = 0.619 | 0.224 | p = 0.508 |
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Kurowska, A.; Bodys-Cupak, I.; Staszkiewicz, M.; Szklarczyk, J.; Zalewska-Puchała, J.; Kliś-Kalinowska, A.; Makara-Studzińska, M.; Majda, A. Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People. Int. J. Environ. Res. Public Health 2020, 17, 3623. https://doi.org/10.3390/ijerph17103623
Kurowska A, Bodys-Cupak I, Staszkiewicz M, Szklarczyk J, Zalewska-Puchała J, Kliś-Kalinowska A, Makara-Studzińska M, Majda A. Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People. International Journal of Environmental Research and Public Health. 2020; 17(10):3623. https://doi.org/10.3390/ijerph17103623
Chicago/Turabian StyleKurowska, Anna, Iwona Bodys-Cupak, Magdalena Staszkiewicz, Joanna Szklarczyk, Joanna Zalewska-Puchała, Anna Kliś-Kalinowska, Marta Makara-Studzińska, and Anna Majda. 2020. "Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People" International Journal of Environmental Research and Public Health 17, no. 10: 3623. https://doi.org/10.3390/ijerph17103623