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Management of STEC Gastroenteritis: Is There a Role for Probiotics?

Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123, Italy
Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy
Department of Public Health, University of Naples Federico II, Napoli 80138, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2019, 16(9), 1649;
Received: 21 March 2019 / Revised: 29 April 2019 / Accepted: 9 May 2019 / Published: 12 May 2019
(This article belongs to the Section Children's Health)
Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention. View Full-Text
Keywords: “Shiga-Toxigenic Escherichia coli” [Mesh]; “Probiotics” [Mesh]; “Microbiota” [Mesh]; “Hemolytic-Uremic Syndrome” [Mesh] “Shiga-Toxigenic Escherichia coli” [Mesh]; “Probiotics” [Mesh]; “Microbiota” [Mesh]; “Hemolytic-Uremic Syndrome” [Mesh]
MDPI and ACS Style

Giordano, M.; Baldassarre, M.E.; Palmieri, V.; Torres, D.D.; Carbone, V.; Santangelo, L.; Gentile, F.; Panza, R.; Di Mauro, F.; Capozza, M.; Di Mauro, A.; Laforgia, N. Management of STEC Gastroenteritis: Is There a Role for Probiotics? Int. J. Environ. Res. Public Health 2019, 16, 1649.

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