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Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

1
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
2
Women’s Health Research Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan
3
School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
5
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
6
Division of Infertility Clinic, Lee Womens’ Hospital, Taichung 406, Taiwan
7
Epidemiology and Biostatistics Center, Changhua Christian Hospital, Changhua 50006, Taiwan
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2019, 16(6), 995; https://doi.org/10.3390/ijerph16060995
Received: 3 February 2019 / Revised: 5 March 2019 / Accepted: 17 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Big Data, Decision Models, and Public Health)
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PDF [320 KB, uploaded 19 March 2019]

Abstract

The aim of this study was to examine the association between interleukin (IL) genes polymorphisms and in vitro fertilization (IVF) outcome. A prospective cohort analysis was performed at a Women’s Hospital IVF centre of 1015 female patients undergoing fresh non-donor IVF cycles. The effects of the following six single nucleotide polymorphisms (SNPs) in five IL genes on IVF outcomes were explored: IL-1α (rs1800587 C/T), IL-3 (rs40401 C/T), IL-6 (rs1800795 C/G), IL-15 (rs3806798 A/T), IL-18 (rs187238 C/G) and IL-18 (rs1946518 G/T). The main outcome measures included clinical pregnancy, embryo implantation, abortion and live birth rates. There were no statistically significant differences in clinical pregnancy, embryo implantation and live birth rates in the analysis of 1015 patients attempting their first cycle of IVF. Infertile women with IL-3 homozygous major genotype had a higher abortion rate than those with heterozygous and homozygous minor genotype (16.5% vs. 7.9%, P = 0.025). In conclusion, our results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients. Future studies with inclusion of other ethnic populations must be conducted to confirm the findings of this study. View Full-Text
Keywords: abortion; IVF outcomes; interleukin; polymorphism abortion; IVF outcomes; interleukin; polymorphism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wu, C.-H.; Lee, T.-H.; Yang, S.-F.; Tsao, H.-M.; Chang, Y.-J.; Chou, C.-H.; Lee, M.-S. Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles. Int. J. Environ. Res. Public Health 2019, 16, 995.

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