Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers
AbstractSome chemotherapies that treat childhood cancers have pulmonary-toxic properties that increase risk for adverse respiratory-health outcomes. PM2.5 causes similar outcomes but its effect among pulmonary compromised cancer survivors is unknown. This case-crossover study identified the PM2.5-associated odds for primary-respiratory hospitalizations and emergency department visits among childhood cancer survivors in Utah. We compared risk among chemotherapy-treated survivors to a cancer-free sample. We calculated 3-day-average PM2.5 by ZIP code and county for event and control days. Conditional logistic regression estimated odds ratios. Models were stratified by cause of admission (infection, respiratory disease, asthma), previous chemotherapy, National Ambient Air Quality Standard (NAAQS), and other variables. Results are presented per 10 µg/m3 of PM2.5. 90% of events occurred at 3-day PM2.5 averages <35.4 µg/m3, the NAAQS 24-h standard. For survivors, PM2.5 was associated with respiratory hospitalizations (OR = 1.84, 95% CI = 1.13–3.00) and hospitalizations from respiratory infection (OR = 2.09, 95% CI = 1.06–4.14). Among chemotherapy-treated survivors, the PM2.5-associated odds of respiratory hospitalization (OR = 2.03, 95% CI = 1.14–3.61) were significantly higher than the cancer-free sample (OR = 0.84, 95% CI = 0.57–1.25). This is the first study to report significant associations between PM2.5 and respiratory healthcare encounters in childhood cancer survivors. Chemotherapy-treated survivors displayed the highest odds of hospitalization due to PM2.5 exposure and their risk is significantly higher than a cancer-free sample. View Full-Text
Share & Cite This Article
Ou, J.Y.; Hanson, H.A.; Ramsay, J.M.; Leiser, C.L.; Zhang, Y.; VanDerslice, J.A.; Pope, C.A., III; Kirchhoff, A.C. Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers. Int. J. Environ. Res. Public Health 2019, 16, 1081.
Ou JY, Hanson HA, Ramsay JM, Leiser CL, Zhang Y, VanDerslice JA, Pope CA, III, Kirchhoff AC. Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers. International Journal of Environmental Research and Public Health. 2019; 16(6):1081.Chicago/Turabian Style
Ou, Judy Y.; Hanson, Heidi A.; Ramsay, Joemy M.; Leiser, Claire L.; Zhang, Yue; VanDerslice, James A.; Pope, C. A., III; Kirchhoff, Anne C. 2019. "Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers." Int. J. Environ. Res. Public Health 16, no. 6: 1081.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.