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Open AccessArticle

The Role of Vertical Transmission in the Control of Dengue Fever

1
Simon A. Levin Mathematical, Computational and Modeling Sciences Center, Arizona State University, Tempe, AZ 85287, USA
2
Department of Applied Mathematics, Kyung Hee University, Yongin 446-701, Korea
3
Institute of Natural Sciences, Kyung Hee University, Yongin 446-701, Korea
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(5), 803; https://doi.org/10.3390/ijerph16050803
Received: 10 January 2019 / Revised: 25 February 2019 / Accepted: 27 February 2019 / Published: 5 March 2019
(This article belongs to the Special Issue Mosquito-Borne Disease)
In this work, a two-strain dengue model with vertical transmission in the mosquito population is considered. Although vertical transmission is often ignored in models of dengue fever, we show that effective control of an outbreak of dengue can depend on whether or not the vertical transmission is a significant mode of disease transmission. We model the effect of a control strategy aimed at reducing human-mosquito transmissions in an optimal control framework. As the likelihood of vertical transmission increases, outbreaks become more difficult and expensive to control. However, even for low levels of vertical transmission, the additional, uncontrolled, transmission from infected mosquito to eggs may undercut the effectiveness of any control function. This is of particular importance in regions where existing control policies may be effective and the endemic strain does not exhibit vertical transmission. If a novel strain that does exhibit vertical transmission invades, then existing, formerly effective, control policies may no longer be sufficient. Therefore, public health officials should pay more attention to the role of vertical transmission for more effective interventions and policy. View Full-Text
Keywords: two-strain dengue model; vertical transmission; basic reproductive number; optimal control interventions two-strain dengue model; vertical transmission; basic reproductive number; optimal control interventions
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MDPI and ACS Style

Murillo, D.; Murillo, A.; Lee, S. The Role of Vertical Transmission in the Control of Dengue Fever. Int. J. Environ. Res. Public Health 2019, 16, 803. https://doi.org/10.3390/ijerph16050803

AMA Style

Murillo D, Murillo A, Lee S. The Role of Vertical Transmission in the Control of Dengue Fever. International Journal of Environmental Research and Public Health. 2019; 16(5):803. https://doi.org/10.3390/ijerph16050803

Chicago/Turabian Style

Murillo, David; Murillo, Anarina; Lee, Sunmi. 2019. "The Role of Vertical Transmission in the Control of Dengue Fever" Int. J. Environ. Res. Public Health 16, no. 5: 803. https://doi.org/10.3390/ijerph16050803

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