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Open AccessArticle

The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day

1
Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
2
School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(4), 553; https://doi.org/10.3390/ijerph16040553
Received: 3 January 2019 / Revised: 2 February 2019 / Accepted: 12 February 2019 / Published: 14 February 2019
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Abstract

A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide. View Full-Text
Keywords: Flurochloridone; subchronic toxicity; NOAEL; male reproductive system Flurochloridone; subchronic toxicity; NOAEL; male reproductive system
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Zhu, H.; Li, R.; Zhou, S.; Zhang, S.; Wang, Y.; Liu, S.; Song, Q.; Chang, X.; Zhang, Y.; Liu, L.; Tang, L.; Zhou, Z. The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day. Int. J. Environ. Res. Public Health 2019, 16, 553.

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