Next Article in Journal
Should We Be Trained to Train? Nursing Students’ and Newly Qualified Nurses’ Perception on Good Lecturers and Good Clinical Preceptors
Previous Article in Journal
Characteristics of Bacterial Community and Function in Paddy Soil Profile around Antimony Mine and Its Response to Antimony and Arsenic Contamination
Open AccessArticle

Correlation between Executive Network Integrity and Sarcopenia in Patients with Parkinson’s Disease

1
Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan
2
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan
3
Brain Research Center, National Yang-Ming University, Taipei 11221, Taiwan
4
Institute of Neuroscience, National Yang Ming University, Taipei 11221, Taiwan
5
Department of Physical Medicine and Rehabilitation, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83305, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(24), 4884; https://doi.org/10.3390/ijerph16244884
Received: 3 November 2019 / Revised: 2 December 2019 / Accepted: 3 December 2019 / Published: 4 December 2019
Background: Sarcopenia is critically associated with morbidity and mortality in the progression of Parkinson’s disease (PD). However, analyses of clinical severity and brain changes, such as white matter (WM) alterations in PD patients with sarcopenia are limited. Further understanding of the factors associated with sarcopenia may provide a focused screen and potential for early intervention in PD patients. Methods: 52 PD patients and 19 healthy participants accepted dual-energy X-ray absorptiometry to measure the body composition. Using diffusion tensor imaging, the difference of WM integrity was measured between PD patients with sarcopenia (PDSa) and without sarcopenia (PDNSa). Multivariate analysis was performed to explore the relationships between clinical factors, WM integrity, and sarcopenia in PD patients. Results: 21 PD patients (40.4%) had sarcopenia. PDSa had a higher Unified Parkinson’s Disease Rating Scale (UPDRS III) score, lower body mass index (BMI) and lower fat weight compared with the PDNSa. Additionally, PDSa patients exhibited lower fractional anisotropy accompanied by higher radial diffusivity and/or higher mean diffusivity in the fronto-striato-thalamic circuits, including bilateral cingulum, left superior longitudinal fasciculus, left genu of corpus callosum, and right anterior thalamic radiation, which participate in the executive function. In addition, decreased muscle mass was associated with worse WM integrity in these regions. Multiple linear regression analysis revealed that WM integrity in the left cingulum, right anterior thalamic radiation, together with gender (male) significantly predicted muscle mass in PD patients. Conclusions: WM alterations in the executive network, such as the fronto-striato-thalamic circuits, may indicate a risk factor for ongoing sarcopenia in PD patients. The effectiveness of using executive function to serve as a prodromal marker of sarcopenia in PD patients should be evaluated in future studies. View Full-Text
Keywords: neurodegenerative disorder; muscle atrophy; executive function; fronto-striato-thalamic circuits; diffusion tensor imaging neurodegenerative disorder; muscle atrophy; executive function; fronto-striato-thalamic circuits; diffusion tensor imaging
Show Figures

Figure 1

MDPI and ACS Style

Lee, C.-Y.; Chen, H.-L.; Chen, P.-C.; Chen, Y.-S.; Chiang, P.-L.; Wang, C.-K.; Lu, C.-H.; Chen, M.-H.; Chou, K.-H.; Huang, Y.-C.; Lin, W.-C. Correlation between Executive Network Integrity and Sarcopenia in Patients with Parkinson’s Disease. Int. J. Environ. Res. Public Health 2019, 16, 4884.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop