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Open AccessArticle

Exposure to Dental Filling Materials and the Risk of Dementia: A Population-Based Nested Case Control Study in Taiwan

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Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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NEVRON International Medical Center, 690078 Vladivostok, Russia
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Graduate School of Oral Medicine, Department of Oral Health Promotion, Matsumoto Dental University, 1780, Gobara, Hirooka, Shiojiri, Nagano 399-0781, Japan
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School of Health Policy and Management, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Department of Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Graduate Institute of Integrated Medicine, Chung Shan Medical University, Hospital, Taichung 40201, Taiwan
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Department of Psychiatry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(18), 3283; https://doi.org/10.3390/ijerph16183283
Received: 2 August 2019 / Revised: 30 August 2019 / Accepted: 4 September 2019 / Published: 6 September 2019
When studying the range of toxic substances triggering dementia, special attention should be paid to the materials used in dental practice, particularly to dental fillings containing amalgam. This necessitated conducting large-scale epidemiologic studies. The aim of our research was to determine the risk factors for developing dementia when filling materials containing amalgam are used in dental practice. In order to achieve the set goals, the following tasks were undertaken: (1) The social and demographic characteristics of the examined patients were studied; (2) the spectrum of concomitant somatic diseases was determined in patients of different gender and age; and (3) the relationship between dementia incidence and the volume of dental filling material containing amalgam was identified in patients with different somatic diseases. In general, the research conducted did not reveal any direct relationship between the development of dementia and the volume of filling material containing amalgam. However, among the people with dementia, there were persons for whom its progression was accelerated in cases where a large volume of dental filling material containing amalgam was present. View Full-Text
Keywords: dementia; amalgam; dental fillings; advanced age; nested case control study dementia; amalgam; dental fillings; advanced age; nested case control study
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Mikhailichenko, N.; Yagami, K.; Chiou, J.-Y.; Huang, J.-Y.; Wang, Y.-H.; Wei, J. .-C.; Lai, T.-J. Exposure to Dental Filling Materials and the Risk of Dementia: A Population-Based Nested Case Control Study in Taiwan. Int. J. Environ. Res. Public Health 2019, 16, 3283.

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