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Open AccessArticle

Dermatologic Vasculature Diseases as a Risk Factor of Subconjunctival Hemorrhage

1,2,†, 3,4,5,†, 6, 7,8, 9, 1,10,11,12,* and 6,10,*
1
Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
2
Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
3
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333, Taiwan
4
Department of Medicine, Chang Gung University College of Medicine, Taoyuan 333, Taiwan
5
Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 333, Taiwan
6
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
7
Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 204, Taiwan
8
Department of Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan
9
Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
10
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
11
Department of Optometry, Chung Shan Medical University, Taichung 402, Taiwan
12
Department of Exercise and Health Promotion, Chung Chou University of Science and Technology, Changhua 500, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Int. J. Environ. Res. Public Health 2019, 16(16), 2865; https://doi.org/10.3390/ijerph16162865
Received: 24 June 2019 / Revised: 5 August 2019 / Accepted: 8 August 2019 / Published: 10 August 2019
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Abstract

To evaluate the relationship between subconjunctival hemorrhage (SCH) and dermatologic vasculature diseases (DVDs) via the national health insurance research database (NHIRD) of Taiwan. This retrospective cohort study used data from the NHIRD for the 2009 to 2013 period. Patients diagnosed with DVDs were enrolled in the study group, and a propensity score-matching population was selected as the control group after exclusion. The main outcome was set as the development of SCH in both groups. Multivariable Cox regression analysis and survival analysis were performed to estimate the adjusted hazard ratio (aHR) and cumulative probability of SCH. A total number of 3426 patients were enrolled and split equally into the study and the control groups. There was no prominent difference between the age, gender, urbanization, income level, systemic co-morbidities, and ocular diseases between the two groups after matching. During the whole study period, 131 patients in the study group and 98 patients in the control group developed SCH with a significant higher aHR of 2.69 in the study group (p < 0.05). In the survival analysis, the study group also demonstrated a higher cumulative probability of developing SCH than the control group throughout the study period (p = 0.02). In conclusion, the presence of DVDs may be a risk factor for the development of SCH. View Full-Text
Keywords: subconjunctival hemorrhage; vascular; hemangioma; teleangiectasias; dermatological subconjunctival hemorrhage; vascular; hemangioma; teleangiectasias; dermatological
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MDPI and ACS Style

Lee, C.-Y.; Chen, H.-C.; Huang, J.-Y.; Sun, C.-C.; Yeh, C.-B.; Lin, H.-Y.; Yang, S.-F. Dermatologic Vasculature Diseases as a Risk Factor of Subconjunctival Hemorrhage. Int. J. Environ. Res. Public Health 2019, 16, 2865.

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