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Int. J. Environ. Res. Public Health 2019, 16(1), 43; https://doi.org/10.3390/ijerph16010043

Relationship between Serum Omega-3 Fatty Acid and Asthma Endpoints

1
Occupational Medicine Division and Centre for Environmental and Occupational Health Research, School of Public Health and Family Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa
2
Molecular Allergy Research Laboratory, School of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Douglas, QLD 4814, Australia
3
Centre of Excellence for Nutrition, North-West University, Potchefstroom 2520, South Africa
4
Department of Environmental and Occupational Studies, Cape Peninsula University of Technology (CPUT), Cape Town 7535, South Africa
*
Author to whom correspondence should be addressed.
Received: 30 August 2018 / Revised: 10 December 2018 / Accepted: 20 December 2018 / Published: 25 December 2018
(This article belongs to the Special Issue Asthma Risk and Prevention)
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PDF [324 KB, uploaded 25 December 2018]

Abstract

Recent studies have highlighted the potential protective role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in asthma. This study aimed at determining the association between seafood intake, serum PUFA composition and clinical endpoints of asthma in adults. A cross-sectional study of 642 subjects used the European Committee Respiratory Health Survey (ECRHS) questionnaire, skin prick tests, spirometry and methacholine challenge tests following ATS guidelines. Sera was analysed for n-3 and n-6 PUFA composition. Subjects had a mean age of 34 years, were largely female (65%) and 51% were current smokers. While 99% reported fish consumption, rock lobster, mussels, squid and abalone were also consumed less frequently. The prevalence of asthma symptoms was 11%, current asthma (ECRHS definition) was 8% and non-specific bronchial hyperresponsiveness (NSBH) was much higher (26%) In adjusted models the n-3 PUFAs 20:5 (EPA) and 22:5 (DPA) were significantly associated with a decreased risk of having NSBH. Total n-3 PUFA composition was associated with decreased NSBH risk (OR = 0.92), while high n-6 PUFA composition was associated with an increased risk (OR = 1.14). View Full-Text
Keywords: non-specific bronchial hyperresponsiveness; polyunsaturated fatty acids; omega-3 fatty acids; omega-6 fatty acids; asthma clinical endpoints non-specific bronchial hyperresponsiveness; polyunsaturated fatty acids; omega-3 fatty acids; omega-6 fatty acids; asthma clinical endpoints
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Adams, S.; Lopata, A.L.; Smuts, C.M.; Baatjies, R.; Jeebhay, M.F. Relationship between Serum Omega-3 Fatty Acid and Asthma Endpoints. Int. J. Environ. Res. Public Health 2019, 16, 43.

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