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Open AccessFeature PaperReview

Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma

1
Department of Biology, Jackson State University, 1400 Lynch Street, Box 18540, Jackson, MS 39217, USA
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Research Centers in Minority Institutions Center for Environmental Health (RCMI-CEH), Jackson State University, 1400 Lynch Street, Box 18540, Jackson, MS 39217, USA
3
Natural Chemotherapeutics Research Laboratory, Jackson State University, 1400 Lynch Street, Box 18540, Jackson, MS 39217, USA
4
Division of Pediatric Hematology/Oncology, Department of Pediatrics, P.O. Box 850, M.C. H085, Pennsylvania State University, Hershey Medical Center, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(7), 1442; https://doi.org/10.3390/ijerph15071442
Received: 11 May 2018 / Revised: 5 July 2018 / Accepted: 5 July 2018 / Published: 9 July 2018
Basal cell carcinoma (BCC) is the most frequently occurring form of all cancers. The cost of care for BCC is one of the highest for all cancers in the Medicare population in the United States. Activation of Hedgehog (Hh) signaling pathway appears to be a key driver of BCC development. Studies involving mouse models have provided evidence that activation of the glioma-associated oncogene (GLI) family of transcription factors is a key step in the initiation of the tumorigenic program leading to BCC. Activation of the Wnt pathway is also observed in BCCs. In addition, the Wnt signaling pathway has been shown to be required in Hh pathway-driven development of BCC in a mouse model. Cross-talks between Wnt and Hh pathways have been observed at different levels, yet the mechanisms of these cross-talks are not fully understood. In this review, we examine the mechanism of cross-talk between Wnt and Hh signaling in BCC development and its potential relevance for treatment. Recent studies have identified insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a direct target of the Wnt/β-catenin signaling, as the factor that binds to GLI1 mRNA and upregulates its levels and activities. This mode of regulation of GLI1 appears important in BCC tumorigenesis and could be explored in the treatment of BCCs. View Full-Text
Keywords: basal cell carcinoma; Hh; Wnt; cross-talk; IGF2BP1; GLI1; therapeutic mechanisms basal cell carcinoma; Hh; Wnt; cross-talk; IGF2BP1; GLI1; therapeutic mechanisms
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Noubissi, F.K.; Yedjou, C.G.; Spiegelman, V.S.; Tchounwou, P.B. Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma. Int. J. Environ. Res. Public Health 2018, 15, 1442.

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