C. elegans—An Emerging Model to Study Metal-Induced RAGE-Related Pathologies
Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Forchheimer Building, Room 209, Bronx, New York, NY 10461, USA
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Int. J. Environ. Res. Public Health 2018, 15(7), 1407; https://doi.org/10.3390/ijerph15071407
Received: 8 June 2018 / Revised: 29 June 2018 / Accepted: 3 July 2018 / Published: 4 July 2018
(This article belongs to the Special Issue Studies on Heavy Metals and Health)
The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, C. elegans has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.
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Keywords:
receptor for advanced glycation end products; methylmercury; selenium; zinc; arsenic; manganese; C. elegans
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MDPI and ACS Style
Pinkas, A.; Cunha Martins, A., Jr.; Aschner, M. C. elegans—An Emerging Model to Study Metal-Induced RAGE-Related Pathologies. Int. J. Environ. Res. Public Health 2018, 15, 1407.
AMA Style
Pinkas A, Cunha Martins A Jr., Aschner M. C. elegans—An Emerging Model to Study Metal-Induced RAGE-Related Pathologies. International Journal of Environmental Research and Public Health. 2018; 15(7):1407.
Chicago/Turabian StylePinkas, Adi; Cunha Martins, Airton, Jr.; Aschner, Michael. 2018. "C. elegans—An Emerging Model to Study Metal-Induced RAGE-Related Pathologies" Int. J. Environ. Res. Public Health 15, no. 7: 1407.
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