Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AAPC | Annual Average Percentage Changes |
AIRTUM | Italian Network of Cancer Registries |
APC | Annual Percentage Change |
ASR | age-specific rates |
BL | Burkitt Lymphoma |
BYM | Besag-York-Mollie |
Cis | Confidence Intervals |
CMD | Chronic myeloid disorders |
CNS | Central Nervous System |
EU | European Union |
GAM | Geographical Analysis Machine |
GPCR | general population-based cancer registries |
IARC | International Agency for research on cancer |
ICCC | International Classification of Childhood Cancer |
ICD-O | International Classification of Diseases for Oncology |
IICC | International Incidence of Childhood Cancer |
ISTAT | Italian Statistics Institute |
MDS | Myelodysplastic syndromes |
PP | Palermo Province |
PPCR | Palermo Province Cancer Registry |
PProb | post-probability |
SIR | standardized incidence ratio |
Std-EU | Standardized by age on the European population |
WSR | World standardized rate |
References
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(a) All Tumours | |||||||
Cases in Study | Quality Indicators * | ||||||
Age Group | M n (%) | F n (%) | Total n (%) | M/F | MV n (%) | DCO n (%) | NMV n (%) |
0–14 | 201 (64.4) | 159 (65.4) | 360 (64.9) | 1.26 | 313 (86.9) | 1 (0.3) | 46 (12.8) |
0 | 20 (6.4) | 13 (5.4) | 33 (5.9) | 1.54 | 28 (84.8) | 0 (0.0) | 5 (15.2) |
1–4 | 64 (20.5) | 55 (22.6) | 119 (21.5) | 1.16 | 106 (89.1) | 0 (0.0) | 13 (10.9) |
5–9 | 57 (18.3) | 38 (15.6) | 95 (17.1) | 1.5 | 82 (86.3) | 0 (0.0) | 13 (13.7) |
10–14 | 60 (19.2) | 53 (21.8) | 113 (20.4) | 1.13 | 97 (85.8) | 1 (0.9) | 15 (13.3) |
15–19 | 111 (35.6) | 84 (34.6) | 195 (35.1) | 1.32 | 177 (90.8) | 0 (0.0) | 18 (9.2) |
0–19 | 312 (100) | 243 (100) | 555 (100) | 1.28 | 493 (88.8) | 1 (0.2) | 61 (11.0) |
(b) Malignant Tumours | |||||||
Cases in Study | Quality Indicators * | ||||||
Age Group | M n (%) | F n (%) | Total n (%) | M/F | MV n (%) | DCO n (%) | NMV n (%) |
0–14 | 175 (62.7) | 144 (65.2) | 319 (63.8) | 1.21 | 285 (89.4) | 1 (0.3) | 33 (10.3) |
0 | 17 (6.1) | 13 (5.9) | 30 (6.0) | 1.31 | 26 (86.7) | 0 (0.0) | 4 (13.3) |
1–4 | 57 (20.4) | 50 (22.7) | 107 (21.4) | 1.14 | 98 (91.6) | 0 (0.0) | 9 (8.4) |
5–9 | 49 (17.6) | 33 (14.9) | 82 (16.4) | 1.48 | 72 (87.8) | 0 (0.0) | 10 (12.2) |
10–14 | 52 (18.6) | 48 (21.7) | 100 (20.0) | 1.08 | 89 (89.0) | 1 (1.0) | 10 (10.0) |
15–19 | 104 (37.3) | 77 (34.8) | 181 (36.2) | 1.35 | 171 (94.5) | 0 (0.0) | 10 (5.5) |
0–19 | 279 (100) | 221 (100) | 500 (100) | 1.26 | 456 (91.2) | 1 (0.2) | 43 (8.6) |
ICCC-3 Main Groups | Children (0–14 Age Group) | Adolescents (15–19 Age Group) | ||
---|---|---|---|---|
n of Cases | % | n of Cases | % | |
I LEUKEMIA | 99 | 28 | 27 | 14 |
a Lymphoid | 73 | 74 | 17 | 63 |
b Acute myeloid | 20 | 20 | 9 | 33 |
c CMD | - | - | - | - |
d MDS & other | 3 | 3 | 1 | 4 |
e Unspecified | 3 | 3 | - | - |
II LYMPHOMA & RELATED | 41 | 11 | 60 | 31 |
a Hodgkin | 21 | 51 | 37 | 62 |
b Non-Hodgkin except BL | 7 | 17 | 19 | 32 |
c Burkitt (BL) | 6 | 15 | 1 | 1.5 |
d Lymphoreticular | 6 | 15 | 2 | 3 |
e Unspecified | 1 | 2 | 1 | 1.5 |
III CNS NEOPLASMS | 91 | 25 | 24 | 12 |
a Ependymoma | 3 | 3 | 1 | 4 |
b Astrocytoma | 31 | 34 | 6 | 25 |
c CNS embryonal | 8 | 9 | 5 | 21 |
d Other gliomas | 7 | 8 | 2 | 8 |
e Other specified | 11 | 12 | 5 | 21 |
f Unspecified CNS | 31 | 34 | 5 | 21 |
IV NEUROBLASTOMA | 37 | 10 | - | - |
a (Ganglio) neuriblastoma | 35 | 95 | - | - |
b Peripheral nervous | 2 | 5 | - | - |
V RETINOBLASTOMA | 6 | 2 | 0 | 0 |
VI RENAL TUMOURS | 19 | 5 | 2 | 1 |
a Nephroblastoma | 17 | 89 | 1 | 50 |
b Renal carcinoma | 2 | 11 | 1 | 50 |
c Unspecified | - | - | - | - |
VII HEPATIC TUMOURS | 3 | 1 | 1 | 1 |
a Hepatoblastoma | 3 | 100 | - | - |
b Hepatic carcinoma | - | - | 100 | 100 |
c Unspecified | - | - | - | - |
VIII BONE TUMOURS | 18 | 5 | 12 | 6 |
a Oteosarcoma | 8 | 44 | 1 | 8 |
b Chondrosarcoma | - | - | - | - |
c Ewing & related | 7 | 39 | 5 | 42 |
d Other specified | - | - | - | - |
e Unspecified | 3 | 17 | 6 | 50 |
IX SOFT TISSUE SARCOMA | 20 | 6 | 11 | 6 |
a Rhabdomyosarcoma | 10 | 50 | 1 | 9 |
b Fibrosarcoma | 5 | 25 | 4 | 36 |
c Kaposi sarcoma | - | - | - | - |
d Other specified | 4 | 20 | 6 | 55 |
e Unspecified | 1 | 5 | - | - |
X GERM CELL TUMOURS | 10 | 3 | 15 | 8 |
a CNS germ cell | 2 | 20 | 10 | 66 |
b Other extragonadal | 4 | 40 | - | - |
c Gonadal germ cell | 4 | 40 | 3 | 20 |
d Gonadal carcinoma | - | - | 1 | 7 |
e Unspecified gonadal | - | - | 1 | 7 |
XI CARCINOMA & MELANOMA | 9 | 3 | 42 | 22 |
a Adrenocortical | - | - | 1 | 2 |
b Thyroid | 6 | 67 | 27 | 64 |
c Nasopharyngel | 1 | 11 | 3 | 7 |
d Melanoma | 1 | 11 | 3 | 7 |
e Skin carcinoma | - | - | 4 | 10 |
f Other & unspecified | 1 | 11 | 4 | 10 |
XII OTHER & UNSPEFIED | 7 | 2 | 1 | 1 |
a Other specified | - | - | - | - |
b Other unspecified | 7 | 100 | 1 | 100 |
TOTAL | 360 | 100 | 195 | 100 |
(a) | 0–14 Years | 15–19 Years | ||
Observed Survival % (Kaplan-Meier Method) | Overall (95%CI) | Overall (95%CI) | ||
PPCR (2003–2012) | 82% (78–87) | 86% (81–91) | ||
AIRTUM POOL (2003–2008) | 82% (80–83) | 86% (84–87) | ||
(b) | Age Groups | |||
Observed survival % (Actuarial Method) | <1 (95%CI) | 1–4 (95%CI) | 5–9 (95%CI) | 10–14 (95%CI) |
PPCR (2003–2007) | 86% (75–99) | 86% (80–93) | 81% (73–90) | 80% (73–88) |
EUROCARE-5 (2000–2007) | 78% (76–79) | 79% (78–80) | 78% (77–79) | 77% (76–78) |
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Share and Cite
Mazzucco, W.; Cusimano, R.; Mazzola, S.; Rudisi, G.; Zarcone, M.; Marotta, C.; Graziano, G.; D’Angelo, P.; Vitale, F. Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance. Int. J. Environ. Res. Public Health 2018, 15, 1344. https://doi.org/10.3390/ijerph15071344
Mazzucco W, Cusimano R, Mazzola S, Rudisi G, Zarcone M, Marotta C, Graziano G, D’Angelo P, Vitale F. Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance. International Journal of Environmental Research and Public Health. 2018; 15(7):1344. https://doi.org/10.3390/ijerph15071344
Chicago/Turabian StyleMazzucco, Walter, Rosanna Cusimano, Sergio Mazzola, Giuseppa Rudisi, Maurizio Zarcone, Claudia Marotta, Giorgio Graziano, Paolo D’Angelo, and Francesco Vitale. 2018. "Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance" International Journal of Environmental Research and Public Health 15, no. 7: 1344. https://doi.org/10.3390/ijerph15071344