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Int. J. Environ. Res. Public Health 2018, 15(6), 1229;

Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry: A New Paradigm in Occupational Health

Institute for Medical Research and Occupational Health, 10 000 Zagreb, Croatia
Institute of Occupational Medicine (IOM), Centre for Human Exposure Science (CHES), Edinburgh EH14 4AP, UK
Centre for Environment and Health, University of Leuven, 3000 Leuven, Belgium
Santé Publique France, French National Public Health Agency, 94 415 Saint-Maurice, France
IDEWE, Knowledge, Information and Research Center, 3001 Heverlee, Belgium
Unit for Nutrition Research, The National University Hospital of Iceland, 101 Reykjavik, Iceland
Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, 101 Reykjavik, Iceland
Department of Public Health, University of Naples Federico II, 80131 Naples, Italy
Institut National de Recherche et de Sécurité, Vandoeuvre CEDEX, 54500 Vandœuvre-lès-Nancy, France
H&TRC—Health & Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisboa, Portugal
Landscape, Environment, Agriculture and Food, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal
Centro de Investigação e Estudos em Saúde Pública, Escola Nacional de Saúde Pública, Universidade Nova de Lisboa, 1600-560 Lisboa, Portugal
Center for Public Health, Medical University of Vienna, 1090 Vienna, Austria
Author to whom correspondence should be addressed.
Received: 27 April 2018 / Revised: 25 May 2018 / Accepted: 7 June 2018 / Published: 11 June 2018
(This article belongs to the Section Occupational Safety and Health)
Full-Text   |   PDF [2547 KB, uploaded 11 June 2018]   |  


Endocrine disruptors (EDs) belong to large and diverse groups of agents that may cause multiple biological effects associated with, for example, hormone imbalance and infertility, chronic diseases such as diabetes, genome damage and cancer. The health risks related with the exposure to EDs are typically underestimated, less well characterized, and not regulated to the same extent as, for example, carcinogens. The increased production and utilization of identified or suspected EDs in many different technological processes raises new challenges with respect to occupational exposure settings and associated health risks. Due to the specific profile of health risk, occupational exposure to EDs demands a new paradigm in health risk assessment, redefinition of exposure assessment, new effects biomarkers for occupational health surveillance and definition of limit values. The construction and plastics industries are among the strongest economic sectors, employing millions of workers globally. They also use large quantities of chemicals that are known or suspected EDs. Focusing on these two industries, this short communication discusses: (a) why occupational exposure to EDs needs a more specific approach to occupational health risk assessments, (b) identifies the current knowledge gaps, and (c) identifies and gives a rationale for a future occupational health paradigm, which will include ED biomarkers as a relevant parameter in occupational health risk assessment, surveillance and exposure prevention. View Full-Text
Keywords: endocrine disruption; construction sector; plastics industry; fertility; biomarkers endocrine disruption; construction sector; plastics industry; fertility; biomarkers

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Fucic, A.; Galea, K.S.; Duca, R.C.; El Yamani, M.; Frery, N.; Godderis, L.; Halldorsson, T.I.; Iavicoli, I.; Ndaw, S.; Ribeiro, E.; Viegas, S.; Moshammer, H. Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry: A New Paradigm in Occupational Health. Int. J. Environ. Res. Public Health 2018, 15, 1229.

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