Alcoholism: A Multi-Systemic Cellular Insult to Organs
by
Ucee Dguzeh 1,†,
Natasha C. Haddad 2,†,
Kathia T. S. Smith 2,†,
John O. Johnson 2,
Angelia A. Doye 3,
Judith K. Gwathmey 3,4 and
Georges E. Haddad 2,*
Ucee Dguzeh 1,†,
Natasha C. Haddad 2,†,
Kathia T. S. Smith 2,†,
John O. Johnson 2,
Angelia A. Doye 3,
Judith K. Gwathmey 3,4 and
Georges E. Haddad 2,*
1
Department of Physiology, New Jersey Medical School Rutgers, 185 S Orange Ave, Newark, NJ 07103, USA
2
Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W Street, NW, #2309, Washington, DC 20059, USA
3
Gwathmey Inc., Cambridge, MA 02138, USA
4
School of Medicine, Boston University, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2018, 15(6), 1083; https://doi.org/10.3390/ijerph15061083
Received: 19 February 2018 / Revised: 13 May 2018 / Accepted: 16 May 2018 / Published: 28 May 2018
(This article belongs to the Special Issue Proceedings of Research Centers at Minority Institutions (RCMI) Translational Science 2017 Conference)
Alcohol abuse can affect more than the heart and the liver. Many observers often do not appreciate the complex and differing aspects of alcohol’s effects in pathophysiologies that have been reported in multiple organs. Chronic alcohol abuse is known to be associated with pathophysiological changes that often result in life-threatening clinical outcomes, e.g., breast and colon cancer, pancreatic disease, cirrhosis of the liver, diabetes, osteoporosis, arthritis, kidney disease, immune system dysfunction, hypertension, coronary artery disease, cardiomyopathy, and can be as far-reaching as to cause central nervous system disorders. In this review article, we will discuss the various organs impacted by alcohol abuse. The lack of clear guidelines on the amount and frequency of alcohol intake, complicated by personal demographics, make extrapolations to real-life practices at best difficult for public health policy-makers.
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MDPI and ACS Style
Dguzeh, U.; Haddad, N.C.; Smith, K.T.S.; Johnson, J.O.; Doye, A.A.; Gwathmey, J.K.; Haddad, G.E. Alcoholism: A Multi-Systemic Cellular Insult to Organs. Int. J. Environ. Res. Public Health 2018, 15, 1083.
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