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Int. J. Environ. Res. Public Health 2018, 15(2), 299;

Urinary Arsenic in Human Samples from Areas Characterized by Natural or Anthropogenic Pollution in Italy

National Research Council—Institute of Clinical Physiology, 56100 Pisa, Italy
Laboratory of Experimental and Clinical Toxicology, Maugeri Clinical Scientific Institutes, 27100 Pavia, Italy
Author to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 30 January 2018 / Accepted: 7 February 2018 / Published: 9 February 2018
(This article belongs to the Special Issue Arsenic Contamination, Bioavailability and Public Health)
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Arsenic is ubiquitous and has a potentially adverse impact on human health. We compared the distribution of concentrations of urinary inorganic arsenic plus methylated forms (uc(iAs+MMA+DMA)) in four Italian areas with other international studies, and we assessed the relationship between uc(iAs+MMA+DMA) and various exposure factors. We conducted a human biomonitoring study on 271 subjects (132 men) aged 20–44, randomly sampled and stratified by area, gender, and age. Data on environmental and occupational exposure and dietary habits were collected through a questionnaire. Arsenic was speciated using chromatographic separation and inductively coupled mass spectrometry. Associations between uc(iAs+MMA+DMA) and exposure factors were evaluated using the geometric mean ratio (GMR) with a 90% confidence interval by stepwise multiple regression analysis. The 95th percentile value of uc(iAs+MMA+DMA) for the whole sample (86.28 µg/L) was higher than other national studies worldwide. A statistical significant correlation was found between uc(iAs+MMA+DMA) and occupational exposure (GMR: 2.68 [1.79–4.00]), GSTT gene (GMR: 0.68 [0.52–0.80]), consumption of tap water (GMR: 1.35 [1.02–1.77]), seafood (GMR: 1.44 [1.11–1.88]), whole milk (GMR: 1.34 [1.04–1.73]), and fruit/vegetables (GMR: 1.37 [1.03–1.82]). This study demonstrated the utility of uc(iAs+MMA+DMA) as a biomarker to assess environmental exposure. In a public health context, this information could be used to support remedial action, to prevent individuals from being further exposed to environmental arsenic sources. View Full-Text
Keywords: arsenic; epidemiology; biomarker; biomonitoring; urinary species arsenic; epidemiology; biomarker; biomonitoring; urinary species

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Minichilli, F.; Bianchi, F.; Ronchi, A.M.; Gorini, F.; Bustaffa, E. Urinary Arsenic in Human Samples from Areas Characterized by Natural or Anthropogenic Pollution in Italy. Int. J. Environ. Res. Public Health 2018, 15, 299.

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