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Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle

1
Department of Kinesiology, Inha University, Incheon 22212, Korea
2
Department of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon 22212, Korea
3
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea
4
National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
5
Department of Kinesiology, Hannam University, Daejeon 34430, Korea
6
Department of Leisure Sports, Seoil University, Seoul 02192, Korea
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(10), 2301; https://doi.org/10.3390/ijerph15102301
Received: 19 September 2018 / Revised: 14 October 2018 / Accepted: 17 October 2018 / Published: 19 October 2018
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Abstract

Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator of skeletal muscle remodeling and apoptosis. However, the effects of exercise on skeletal muscle remodeling and mitochondria-mediated apoptosis in obese skeletal muscles have not been clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), control plus exercise (CON + EX), high-fat diet (HFD), and HFD plus exercise groups (HFD + EX). After obesity was induced by 20 weeks of 60% HFD feeding, treadmill exercise was performed for 12 weeks. Exercise ameliorated the obesity-induced increase in extramyocyte space and a decrease in the cross-sectional area of the skeletal muscle. In addition, it protected against increases in mitochondria-mediated apoptosis in obese skeletal muscles. These results suggest that exercise as a protective intervention plays an important role in regulating skeletal muscle structure and apoptosis in obese skeletal muscles. View Full-Text
Keywords: obesity; exercise; skeletal muscle; mitochondria; apoptosis obesity; exercise; skeletal muscle; mitochondria; apoptosis
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Heo, J.-W.; Yoo, S.-Z.; No, M.-H.; Park, D.-H.; Kang, J.-H.; Kim, T.-W.; Kim, C.-J.; Seo, D.-Y.; Han, J.; Yoon, J.-H.; Jung, S.-J.; Kwak, H.-B. Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle. Int. J. Environ. Res. Public Health 2018, 15, 2301.

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