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Open AccessArticle

Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?

1
Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland
2
Diabetology Ward, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
3
Institute of Public Health, Pope John Paul II State School of Higher Education, Sidorska 95/97, 21-500 Biała Podlaska, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(1), 19; https://doi.org/10.3390/ijerph15010019
Received: 7 November 2017 / Revised: 17 December 2017 / Accepted: 20 December 2017 / Published: 23 December 2017
A growing interest in the role of vitamin D in metabolic diseases led us to study the relationships between 25-hydroxyvitamin D3 (25(OH)D3) and the profiles of selected adipokines in type 2 diabetic (T2DM) patients. The study comprised 92 type 2 diabetics divided into quartiles regarding 25(OH)D3 concentration. Each group was divided into male and female subgroups. All the studied patients had their anthropometric and biochemical parameters determined. Plasma 25-hydroxyvitamin D3 concentration was determined by HPLC, while the selected adipokines (leptin, adiponectin, resistin and visfatin) by ELISA methods. The ratio of leptin to adiponectin (L/A) was calculated for all the patients. In 85.3% of diabetics a full (<20 ng/mL) or moderate (20–30 ng/mL) vitamin D deficit was found. Irrespective of sex, plasma leptin concentration decreased across increasing quartiles of 25(OH)D3 level. In women, 25(OH)D3 was negatively correlated with BMI, leptin level as well as L/A ratio, and positively with adiponectin concentration. In men, 25(OH)D3 was positively correlated with HDL and negatively with systolic blood pressure (SBP), leptin level and L/A ratio. Considering all the patients, there ocurred a significant negative correlation between 25(OH)D3 and SBP, BMI, WHR, TG, leptin and L/A ratio and positive ones between 25(OH)D3 and both adiponectin and HDL. The results of the study support the existence of the relationship among vitamin D, obesity and leptin in type 2 diabetic patients. View Full-Text
Keywords: vitamin D; adipokines; type 2 diabetes; obesity vitamin D; adipokines; type 2 diabetes; obesity
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Kocot, J.; Dziemidok, P.; Kiełczykowska, M.; Kurzepa, J.; Szcześniak, G.; Musik, I. Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients? Int. J. Environ. Res. Public Health 2018, 15, 19.

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