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Int. J. Environ. Res. Public Health 2017, 14(6), 555;

Ephedra-Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat Diet-Induced Obesity in Rats

Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814 Siksa, Goyang, Gyeonggi-do 10326, Korea
Key Laboratory of Xin’an Medicine, Ministry of Education, Anhui University of Traditional Chinese Medicine, Meishan Road 103, Hefei 230038, China
Department of Life Sciences, Hallym University, Chuncheon, Gangwon-do 24252, Korea
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 17 March 2017 / Revised: 11 May 2017 / Accepted: 15 May 2017 / Published: 23 May 2017
(This article belongs to the Section Global Health)
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Changes in gut microbiota (GM) are closely associated with metabolic syndrome, obesity, type 2 diabetes and so on. Several medicinal herbs, including Ephedra sinica (Es), have anti-obesity effects that ameliorate metabolic disorders. Therefore, in this study we evaluated whether Es maintains its anti-obesity effect through Es-altered gut microbiota (EsM) transplantation. GM was isolated from cecal contents of Es treated and untreated rats following repeated transplants into obese rats via oral gavage over three weeks. High-fat-diet (HFD)-induced obese rats transplanted with EsM lost significant body weight, epididymal fat, and perirenal fat weight, but no remarkable changes were observed in abdominal fat, liver, cecum weight and food efficiency ratio. In addition, treatment with EsM also significantly lowered the fasting blood glucose, serum insulin level, and insulin resistance index. Meanwhile, EsM transplantation significantly reduced gene expression of proinflammatory cytokines interleukin-1 and monocyte chemotactic protein-1. Rats treated with EsM also showed changed GM composition, especially blautia, roseburia and clostridium, significantly reduced the level of endotoxin and markedly increased the acetic acid in feces. Overall, our results demonstrated that EsM ameliorates HFD-induced obesity and related metabolic disorders, like hyperglycemia and insulin resistance, and is strongly associated with modulating the distribution of GM, enterogenous endotoxin and enteral acetic acid. View Full-Text
Keywords: ephedra; microbiota; transplantation; high fat diet; obesity ephedra; microbiota; transplantation; high fat diet; obesity

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Wang, J.-H.; Kim, B.-S.; Han, K.; Kim, H. Ephedra-Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat Diet-Induced Obesity in Rats. Int. J. Environ. Res. Public Health 2017, 14, 555.

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