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Int. J. Environ. Res. Public Health 2017, 14(5), 536;

Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood

Laboratoire de RadioToxicologie Expérimentale, Service de Radiobiologie et d’Epidémiologie, Institut de Radioprotection et de Sûreté Nucléaire, B.P.17, 92262 Fontenay aux Roses CEDEX, France
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 29 March 2017 / Revised: 5 May 2017 / Accepted: 13 May 2017 / Published: 17 May 2017
(This article belongs to the Special Issue Environmental Neurotoxicology)
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Uranium exposure leads to cerebral dysfunction involving for instance biochemical, neurochemical and neurobehavioral effects. Most studies have focused on mechanisms in uranium-exposed adult animals. However, recent data on developing animals have shown that the developing brain is also sensitive to uranium. Models of uranium exposure during brain development highlight the need to improve our understanding of the effects of uranium. In a model in which uranium exposure began from the first day of gestation, we studied the neurobehavioral consequences as well as the progression of hippocampal neurogenesis in animals from dams exposed to uranium. Our results show that 2-month-old rats exposed to uranium from gestational day 1 displayed deficits in special memory and a prominent depressive-like phenotype. Cell proliferation was not disturbed in these animals, as shown by 5-bromo-2′deoxyuridine (BrdU)/neuronal specific nuclear protein (NeuN) immunostaining in the dentate gyrus. However, in some animals, the pyramidal cell layer was dispersed in the CA3 region. From our previous results with the same model, the hypothesis of alterations of neurogenesis at prior stages of development is worth considering, but is probably not the only one. Therefore, further investigations are needed to correlate cerebral dysfunction and its underlying mechanistic pathways. View Full-Text
Keywords: hippocampus; brain development; memory; depression; chronic exposure; uranyl; rodent hippocampus; brain development; memory; depression; chronic exposure; uranyl; rodent

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Dinocourt, C.; Culeux, C.; Legrand, M.; Elie, C.; Lestaevel, P. Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood. Int. J. Environ. Res. Public Health 2017, 14, 536.

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