Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis
Abstract
:1. Introduction
2. Methods
2.1. Literature Search
2.2. Selection Criteria and Data Extraction
2.3. Quality Assessment
2.4. Statistical Analysis
3. Results
3.1. Study Identification and Selection
3.2. Study Characteristics
3.3. Quality Assessment
3.4. LEPR Gene Polymorphism and CVD Risk
3.5. Subgroup Meta-Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Conflicts of Interest
Funding
References
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First Author, Published Year | Ethnicity | Study Design | Male (%) | Mean Age (Years) | Case | Controls | Leptin Receptor Polymorphism | ||
---|---|---|---|---|---|---|---|---|---|
Disease | No. | Matching | No. | ||||||
Abd El-Aziz, 2012 [10] | Egyptian | Case-control | 26.0 | 55.5 | Coronary artery disease | 100 | Age- and sex-matched healthy subjects | 100 | rs1137101 (Gln223Arg) |
Aijälä, 2014 [18] | European | Cohort | 49.1 | 51 | Coronary artery disease, Cardiovascular disease | 303,423 | - | 725,605 | rs1137101 (Gln223Arg), rs1137100 (Lys109Arg) |
Bienertová-Vašku, 2009 [11] | American | Case-control | 71.2 | 56 | Chronic heart failure | 372 | Age- and sex-matched healthy subjects | 407 | rs1137101 (Gln223Arg) |
Elliott, 2009 [19] | European and Asian a | Cohort | Both men and women, the proportion not reported | 20–75 b | Coronary heart disease | 12,148 | - | 29,127 | rs6700896 |
Jin, 2015 [20] | Asian | Case-control | 53.3 | 59 | Coronary artery disease | 120 | Age- and sex-matched healthy subjects | 109 | rs6700896 |
Roszkowska-Gancarz, 2014 [21] | European | Case-control | 57.0 | 47 | Myocardial infarction | 226 | Blood donors and volunteers | 190 | rs1137101 (Gln223Arg), rs1137100 (Lys109Arg), rs8179183 (Lys656Asn) |
Tang, 2015 [12] | Asian | Case-control | 67.5 | 61 | Ischemic stroke | 101 | Age- and sex-matched healthy subjects | 105 | rs1137101 (Gln223Arg), rs1137100 (Lys109Arg), rs8179183 (Lys656Asn) |
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Wu, L.; Sun, D. Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2017, 14, 375. https://doi.org/10.3390/ijerph14040375
Wu L, Sun D. Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2017; 14(4):375. https://doi.org/10.3390/ijerph14040375
Chicago/Turabian StyleWu, Lei, and Dali Sun. 2017. "Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis" International Journal of Environmental Research and Public Health 14, no. 4: 375. https://doi.org/10.3390/ijerph14040375
APA StyleWu, L., & Sun, D. (2017). Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 14(4), 375. https://doi.org/10.3390/ijerph14040375