In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids

Pelfrêne, Aurélie; Cave, Mark R.; Wragg, Joanna; Douay, Francis

doi:10.3390/ijerph14020112

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In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids

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Laboratoire Génie Civil et géo-Environnement (LGCgE), ISA Lille, Yncréa Hauts-de-France, 48 Boulevard Vauban, Lille Cedex 59046, France

British Geological Survey, Keyworth, Nottingham NG12 5GG, UK

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Academic Editor: Jose A. Centeno

Int. J. Environ. Res. Public Health 2017, 14(2), 112; https://doi.org/10.3390/ijerph14020112

Received: 14 December 2016 / Revised: 10 January 2017 / Accepted: 20 January 2017 / Published: 24 January 2017

(This article belongs to the Special Issue Proceedings from the 3rd International Symposium on Environment and Health)

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Abstract

An investigation for assessing pulmonary bioaccessibility of metals from reference materials is presented using simulated lung fluids. The objective of this paper was to contribute to an enhanced understanding of airborne particulate matter and its toxic potential following inhalation. A large set of metallic elements (Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, and Zn) was investigated using three lung fluids (phosphate-buffered saline, Gamble’s solution and artificial lysosomal fluid) on three standard reference materials representing different types of particle sources. Composition of the leaching solution and four solid-to-liquid (S/L) ratios were tested. The results showed that bioaccessibility was speciation- (i.e., distribution) and element-dependent, with percentages varying from 0.04% for Pb to 86.0% for Cd. The higher extraction of metallic elements was obtained with the artificial lysosomal fluid, in which a relative stability of bioaccessibility was observed in a large range of S/L ratios from 1/1000 to 1/10,000. For further investigations, it is suggested that this method be used to assess lung bioaccessibility of metals from smelter-impacted dusts. View Full-Text

Keywords: airborne particulate matter; metallic elements; bioaccessibility; simulated lung fluids

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MDPI and ACS Style

Pelfrêne, A.; Cave, M.R.; Wragg, J.; Douay, F. In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids. Int. J. Environ. Res. Public Health 2017, 14, 112. https://doi.org/10.3390/ijerph14020112

AMA Style

Pelfrêne A, Cave MR, Wragg J, Douay F. In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids. International Journal of Environmental Research and Public Health. 2017; 14(2):112. https://doi.org/10.3390/ijerph14020112

Chicago/Turabian Style

Pelfrêne, Aurélie, Mark R. Cave, Joanna Wragg, and Francis Douay. 2017. "In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids" International Journal of Environmental Research and Public Health 14, no. 2: 112. https://doi.org/10.3390/ijerph14020112

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In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids

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