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Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report

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Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia
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School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia
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Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2017, 14(12), 1553; https://doi.org/10.3390/ijerph14121553
Received: 31 October 2017 / Revised: 1 December 2017 / Accepted: 8 December 2017 / Published: 11 December 2017
Advanced glycation end-products (AGEs) are formed endogenously as a normal ageing process and during food processing. High levels of AGEs have been implicated in the development of both macrovascular disease and microvascular disease. The purpose of this secondary analysis was to determine whether a major AGE species, Nε-carboxymethyllysine (CML), was reduced after weight loss. CML values decreased by 17% after weight loss. Participants with diabetes and pre-diabetes had a lower CML values at baseline and a smaller change in CML than overweight participants without diabetes. We conclude that, in addition to the known health benefits, weight loss may reduce AGEs. Randomized studies of the effect of weight loss on AGE in people with and without type 2 diabetes are needed to confirm these results. View Full-Text
Keywords: advanced glycation end-products; Nε-carboxymethyllysine; weight loss advanced glycation end-products; Nε-carboxymethyllysine; weight loss
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MDPI and ACS Style

Deo, P.; Keogh, J.B.; Price, N.J.; Clifton, P.M. Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report. Int. J. Environ. Res. Public Health 2017, 14, 1553.

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