Next Article in Journal
Surveillance of Clostridium difficile Infections: Results from a Six-Year Retrospective Study in Nine Hospitals of a North Italian Local Health Authority
Next Article in Special Issue
Occurrence of Emerging Micropollutants in Water Systems in Gauteng, Mpumalanga, and North West Provinces, South Africa
Previous Article in Journal
Assessment of Food Safety Knowledge, Attitude, Self-Reported Practices, and Microbiological Hand Hygiene of Food Handlers
Previous Article in Special Issue
Predictors of Urinary 3-Phenoxybenzoic Acid Levels in 50 North Carolina Adults
Article

Serum Polychlorinated Biphenyls Increase and Oxidative Stress Decreases with a Protein-Pacing Caloric Restriction Diet in Obese Men and Women

by 1,2,†, 3,†, 1 and 1,*
1
Human Nutrition and Metabolism Laboratory, Health and Exercise Sciences Department, Skidmore College, 815 North Broadway, Saratoga Springs, NY 12866, USA
2
Department of Kinesiology, California State University-Chico, Chico, CA 95929, USA
3
Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Peter Clifton
Int. J. Environ. Res. Public Health 2017, 14(1), 59; https://doi.org/10.3390/ijerph14010059
Received: 5 October 2016 / Revised: 28 December 2016 / Accepted: 4 January 2017 / Published: 10 January 2017
(This article belongs to the Special Issue Organic Micro-Pollutants and Human Exposure)
The purposes were to compare the effects of a: (1) 12-week P-CR weight loss (WL) diet (Phase 1) between obese men and women and; (2) 52-week modified P-CR (mP-CR) vs. heart healthy (HH) weight maintenance (WM) diet (Phase 2) on serum PCBs and oxidative stress biomarkers (thiobarbituric acid reactive substances, TBARS; total antioxidant capacity, TAC) in 40 obese participants (men, n = 21; women, n = 19). Participants received dietary counseling and monitoring of compliance. PCBs, TBARS, and TAC were assessed at weeks −1 (CON), 12 (WL), and 64 (WM). Following WL (Week 12), concomitant with reductions in TBARS (0.24 ± 0.15 vs. 0.18 ± 0.11 µM; p < 0.01), PCB serum concentrations (86.7 ± 45.6 vs. 115.6 ± 65.9 ng/g lipid; p < 0.01) and TAC (18.9 ± 2.6 vs. 19.9 ± 2.3 nmol/mL; p < 0.02) were increased similarly in men and women. At the end of WM (Week 64), a significant effect of time × group interaction was observed for % change in PCB 170 and 187; whereby mP-CR values were higher compared to HH (PCB170: 19.31% ± 26.48% vs. −6.61% ± 28.88%, p = 0.02; PCB187: −3.04% ± 17.78% vs. −21.4% ± 27.31%, p = 0.04). PCB changes were positively correlated with TBARS levels (r > 0.42, p < 0.05) and negatively correlated with body weight, fat mass, and abdominal fat (r < −0.46, p < 0.02). Our results support mobilization of stored PCBs as well as enhanced redox status following a 12-week P-CR WL diet. Additionally, a 52-week mP-CR WM diet demonstrated an advantage in preventing weight gain relapse accompanied by an increase in circulating PCBs compared to a traditional HH diet. View Full-Text
Keywords: polychlorinated biphenyls (PCBs); oxidative stress; caloric restriction; intermittent-fasting polychlorinated biphenyls (PCBs); oxidative stress; caloric restriction; intermittent-fasting
Show Figures

Figure 1

MDPI and ACS Style

He, F.; Zuo, L.; Ward, E.; Arciero, P.J. Serum Polychlorinated Biphenyls Increase and Oxidative Stress Decreases with a Protein-Pacing Caloric Restriction Diet in Obese Men and Women. Int. J. Environ. Res. Public Health 2017, 14, 59. https://doi.org/10.3390/ijerph14010059

AMA Style

He F, Zuo L, Ward E, Arciero PJ. Serum Polychlorinated Biphenyls Increase and Oxidative Stress Decreases with a Protein-Pacing Caloric Restriction Diet in Obese Men and Women. International Journal of Environmental Research and Public Health. 2017; 14(1):59. https://doi.org/10.3390/ijerph14010059

Chicago/Turabian Style

He, Feng, Li Zuo, Emery Ward, and Paul J. Arciero. 2017. "Serum Polychlorinated Biphenyls Increase and Oxidative Stress Decreases with a Protein-Pacing Caloric Restriction Diet in Obese Men and Women" International Journal of Environmental Research and Public Health 14, no. 1: 59. https://doi.org/10.3390/ijerph14010059

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop