Next Article in Journal
Understanding the Influence of Environment on Adults’ Walking Experiences: A Meta-Synthesis Study
Previous Article in Journal
Quantitative Microbial Risk Assessment in Occupational Settings Applied to the Airborne Human Adenovirus Infection
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2016, 13(7), 732;

The Relation of Moderate Alcohol Consumption to Hyperuricemia in a Rural General Population

Department of Cardiology, the First Hospital of China Medical University, Shenyang 110001, China
Department of Pharmacy, Zhongda Hospital, Southeast University, Nanjing 210009, China
Department of Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 4 June 2016 / Revised: 12 July 2016 / Accepted: 13 July 2016 / Published: 20 July 2016
Full-Text   |   PDF [1289 KB, uploaded 22 July 2016]   |  


Background: although alcohol abuse is known to increase serum uric acid, the relation between moderate drinking and uric acid have remained poorly understood. We performed this study to evaluate whether different alcohol consumption level has different effects on the risk of hyperuricemia based on a rural general population. Method: multi-stage cluster sampling method was used to select a representative sample of individuals aged 35 years or older. Participants were asked to provide information about their alcohol consumption. Data regarding the demographic and lifestyle characteristics and the blood biochemical indexes of these participants were collected by well-trained personnel. Results: in total, 11,039 participants aged 35 years or older were included (4997 men and 6042 women). The prevalence of hyperuricemia in the different male alcohol consumption groups was 11.9% in non-drinkers, 12.6% in moderate drinkers, and 16.3% in heavy drinkers (p < 0.001). In females, the rates were 6.3% in non-drinkers, 8.1% in moderate drinkers, and 6.6% for heavy drinkers (p = 0.818). In males, multivariate logistic regression analyses shows heavy drinkers had an approximately 1.7-fold higher risk of hyperuricemia (OR: 1.657, 95% CI: 1.368 to 2.007, p < 0.001) than non-drinkers; moderate drinkers did not experience a significant increase in risk (OR: 1.232, 95% CI: 0.951 to 1.596, p = 0.114)). Multivariate logistic regression analyses of females showed that, compared with non-drinkers, neither moderate nor heavy drinkers had a significantly increased risk of hyperuricemia (OR: 1.565, 95% CI: 0.521 to 4.695, p = 0.425 for heavy drinkers; OR: 0.897, 95% CI: 0.117 to 6.855, p = 0.916 for moderate drinkers). Conclusions: heavy alcohol consumption increased the risk of hyperuricemia for males but not for females. Among both males and females, moderate alcohol consumption did not increase the risk of hyperuricemia. View Full-Text
Keywords: alcohol; consumption; risk factor; prevalence; hyperuricemia alcohol; consumption; risk factor; prevalence; hyperuricemia

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Li, Z.; Guo, X.; Liu, Y.; Chang, Y.; Sun, Y.; Zhu, G.; Abraham, M.R. The Relation of Moderate Alcohol Consumption to Hyperuricemia in a Rural General Population. Int. J. Environ. Res. Public Health 2016, 13, 732.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top