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Open AccessArticle

Polyethyleneimine Capped Silver Nanoclusters as Efficient Antibacterial Agents

by Dong Xu 1,*,†, Qingyun Wang 1,†, Tao Yang 1, Jianzhong Cao 1, Qinlu Lin 1,*, Zhiqin Yuan 2 and Le Li 3
National Engineering Laboratory for Rice and By-Products Further Processing, Central South University of Forestry & Technology, Changsha 410004, China
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Hunan Ehome Health Technology Inc., Buliding 6# 1715, LvDi Central Square, Yuelu District, Changsha 410023, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Huang-Tsung Chang
Int. J. Environ. Res. Public Health 2016, 13(3), 334;
Received: 2 February 2016 / Revised: 13 March 2016 / Accepted: 14 March 2016 / Published: 18 March 2016
Development of efficient antibacterial agents is critical for human health. In the present study, we investigated the antibacterial activity of polyethyleneimine (PEI)-capped silver nanoclusters (PEI-AgNCs), based on the fact that nanoclusters normally have higher surface-to-volume ratios than traditional nanomaterials and PEI itself has a strong antimicrobial capacity. We synthesized stable silver nanoclusters by altering PEI molecular weight from 0.6 kDa to 25 kDa and characterized them by UV-Vis absorption and fluorescence spectroscopy and high resolution transmission electron microscopy. The sizes of AgNCs were around 2 nm in diameter and were little influenced by the molecular weight of PEIs. The antibacterial abilities of the four PEI-AgNCs were explored on agar plate and in liquid systems. Our results revealed that the antibacterial activity of PEI-AgNCs is excellent and the reduction of PEI molecular weight could result in the increased antibacterial capacity of PEI-AgNCs. Such proposed new materials might be useful as efficient antibacterial agents in practical clinical applications. View Full-Text
Keywords: silver nanoclusters; polyethyleneimine; antibacterial agent silver nanoclusters; polyethyleneimine; antibacterial agent
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MDPI and ACS Style

Xu, D.; Wang, Q.; Yang, T.; Cao, J.; Lin, Q.; Yuan, Z.; Li, L. Polyethyleneimine Capped Silver Nanoclusters as Efficient Antibacterial Agents. Int. J. Environ. Res. Public Health 2016, 13, 334.

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